摘要
实验观察硝苯地平（Nif）对急性胰腺炎（AP）大鼠胰组织钙、线粒体钙含量影响。结果显示：AP大鼠胰组织钙、线粒体钙含量均明显增加。Nif降低钙含量，减轻胰组织损害程度。提示细胞钙稳态失调可能是AP的一个重要发病因素。Nif抑制细胞钙稳态失调，对AP产生治疗作用。
The effect of nifedipine (Nif) was assessed on calcium concentration in pancreatic tissue and mitochondria in rats with acute pancreatitis (AP). The calcium concentration of pancreatic tissue and mitochondria was increased in AP group. But the degree of calcium concentration and the severity of histologic Lesions were markedly decreased in Nif group. Suggest that: The disturbance of intracelular calcium homeosasis may be an important pathogenic factor for AP and Nif may inhibit the disturbance of calcium homeostasis to bring with the therapeutic effect in AP.
出处
《江苏医药》
CAS
CSCD
1994年第7期353-354,共2页
Jiangsu Medical Journal
关键词
胰腺炎
钙稳态失调
钙
硝苯地平
Acute Pancreatitis Calcium Homeostasis Calcium Nifedipine
