1Eckert A, Marques CA, Keil U, Schussel K, Muller WE. Increased apoptotic cell death in sporadic and genetic Alzheimer's disease. Ann N Y Acad Sci. 2003.
2Morris J. H. Alzheimer's disease. In The Neuropathology of Dementia Cambridge University Press, Cambridge, PP. 1997.70 ~ 121.
3Cotman CW. Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiology of Aging,1998,19:29 ~32.
4Kawasumi M, Hashimoto Y, Chiba T, Kanekura K, Yamagishi Y, IshizakaM, TajimaH, Ni ikuraT, Nishimoto I. Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein - relevant insults. Neurosignals, PP. 2002. 236 ~ 50.
5Sherrington R. , Rogaev EJ. Liang Y. et al Cell degeneration induced by amyloid - beta peptides: implications for Alzheimer's disease. J Mol Neurosci ,2004.
6Games D. Adams D. Alessandrini R. et al. , Alzhcimer - type neuropathology in transgenic mice overexpressing V717F β- amyloid protein.Nature, 1995,373:523 ~ 7.
7Busciglio J. Lorenzo A. Yanker BA. et al. , β - amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron, 1995,14:879 ~ 88.
8Jana A, Pahan K. Fibrillar amyloid - beta peptides kill human primary neurons via NADPH oxidase - mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease. J Biol Chem, 2004,279(49) :51451 ~9.
9LaFerla FM. Tindle BT. Haudenschild CC. et al. The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nature Genet, 1995,9:21 ~ 30.
10Yao M, Nguyen TV, Pike CJ. J Neurosci. pp1 149 -58 Beta -amyloid - induced neuronal apoptosis involves c - Jun N - terminal kinase - dependent downregulation of Bcl - w , 2005,25 ( 5 ):
2Brion-JP.The role of neurofibrillary tangles in Alzheimer disease[J].Acta Neurol Belg,1998,98:165-174.
3Anderton-BH,Dayanandan-R,Killick-R,et al.Does dysregulation of the notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease[J].Mol Med Today,2000,6:54-59.
4Cotman CW.Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease[J].Neurobiology of Aging,1998,19:29-32.
5Kawasumi M,Hashimoto Y,Chiba T,et al.Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein -relevant insults[J].Neurosignals,2002,11:236-250.
6Qiao J,Qu QM,Yang JB,et al.A study on the intellectual impairment in patients with Parkinson disease[J].Chin J Clin Rehabil,2002,28:43 -44.
7Selkoe DJ.Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease[J].J Clin Invest,2002,110:1375-1381.
8Weller RO,Massey A,Kuo YM,et al.Cerebrovascular disease is a major factor in the failure of elimination of Abeta from the aging human brain:implications for therapy of Alzheimer's disease[J].Ann NY Acad Sci,2002,977:162-168.
9Carpentier M,Robitaille Y,DesCroseillers L,et al.Declining expression of neprilysin in Alzheimer disease vasculature:possible involvement in cerebral amyloid angiopathy[J].J Neuropathol Exp Neurol,2002,61:849-856.
10Hashimoto Y,Niikura T,Ito Y,et al.Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutation of amyloid precursor protein[J].J Biol Chem,2000,257:34541-34551.