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静注人免疫球蛋白在治疗阿尔茨海默病中的应用 被引量:3

Application of intravenous immunoglobulin in treatment of Alzheimer disease
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摘要 阿尔茨海默病(Alzheimer disease,AD)是最常见的神经退行性疾病。AD已经造成了严重的社会负担,而且目前仍无有效的方法可以治疗。近年来,使用静注人免疫球蛋白(intravenous immunoglobulin,IVIg)治疗AD被认为是一种有潜力的疗法。本文对AD、Aβ级联假说、IVIg治疗AD的作用机制以及临床试验等作一综述,并对未来IVIg治疗AD的研究进行了展望。 Alzheimer disease(AD) is the most common neurodegenerative disorder. Although AD has caused serious economic and social burden,no effective therapy is available up to now. Recently,intravenous immunoblobulin(IVIg)is regarded as a promising therapy for AD. In this paper,AD,amyloid cascade hypothesis,mechanism of IVIg in treatment of AD and the relative clinical trials,as well as the treatment of AD with IVIg in future,are reviewed.
出处 《中国生物制品学杂志》 CAS CSCD 2014年第12期1628-1632,共5页 Chinese Journal of Biologicals
关键词 静注人免疫球蛋白 阿尔茨海默病 Β-淀粉样蛋白 Intravenous immunoblobulin(IVIg) Alzheimer disease(AD) Amyloid-beta protein(Aβ)
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同被引文献37

  • 1张芃,刘琳娜,何功浩,刘睿,张巍,苗建亭,李柱一.Aβ_(20-29)短肽阻断ApoE/Aβ结合并减少Aβ_(1-42)纤维化及其神经毒性的效应作用[J].中国临床神经科学,2009,17(1):1-6. 被引量:1
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