摘要
阿尔茨海默病(Alzheimer disease,AD)是最常见的神经退行性疾病。AD已经造成了严重的社会负担,而且目前仍无有效的方法可以治疗。近年来,使用静注人免疫球蛋白(intravenous immunoglobulin,IVIg)治疗AD被认为是一种有潜力的疗法。本文对AD、Aβ级联假说、IVIg治疗AD的作用机制以及临床试验等作一综述,并对未来IVIg治疗AD的研究进行了展望。
Alzheimer disease(AD) is the most common neurodegenerative disorder. Although AD has caused serious economic and social burden,no effective therapy is available up to now. Recently,intravenous immunoblobulin(IVIg)is regarded as a promising therapy for AD. In this paper,AD,amyloid cascade hypothesis,mechanism of IVIg in treatment of AD and the relative clinical trials,as well as the treatment of AD with IVIg in future,are reviewed.
出处
《中国生物制品学杂志》
CAS
CSCD
2014年第12期1628-1632,共5页
Chinese Journal of Biologicals
关键词
静注人免疫球蛋白
阿尔茨海默病
Β-淀粉样蛋白
Intravenous immunoblobulin(IVIg)
Alzheimer disease(AD)
Amyloid-beta protein(Aβ)