摘要
目的 通过流行病学调查 ,探讨饮酒与代谢综合征的关系。方法 随机多级分层整群抽查上海市成年居民 ,内容涉及问卷咨询、体检、葡萄糖耐量试验和血脂全套。结果 42 0 5例成人完成调查 ,年龄 (5 3 .3± 14 .9)岁 ,男女之比为 1∶1.5 5 ,其中有饮酒习惯者 44 8名 (10 .65 % ) ,男性 40 5例 ,女性 43例 ,男性饮酒率显著高于女性 (2 4.5 3 %对 1.72 % ,P <0 .0 0 0 1)。饮酒组、过量饮酒组腹型肥胖、糖代谢异常、低HDL C血症患病率显著低于相应对照组 ,而高三酰甘油(TG)血症、高血压病患病率则显著高于相应对照组 ,代谢综合征患病率在各组之间差异均无显著性。然而 ,空腹血糖水平和体重指数改变与上述结果并不平行。结论 饮酒对多元代谢紊乱影响复杂 ,一方面饮酒可升高血压和TG ,另一方面又可降低腹型肥胖、糖代谢异常以及低HDL C血症患病率。
Objective To investigate the relationship between alcohol consumption and the multiple metabolic disorders. Methods With randomized multistage stratified cluster sampling,investigations including questionnaires,physical examinations, oral glucose tolerance tests, and blood lipid laboratory tests were performed in Shanghai adults.Results A total of 4205 adults, with 1651 males and 2554 females mean age of 53.3±14.9. 448 subjects (10.65%) were habitual drinking, consisted of 405 males and 43 females.The prevalence of habitual drinking in males was significantly higher than in females(24.53% vs 1.72%, P<0. 0001).The prevalence of abdominal obesity, blood glucose metabolism abnormality (impaired fasting glucose or impaired glucose intolerance or diabetes millitus),and low high-density lipoprotein cholesterol (HDL-C) were significantly lower in habitual drinking group and excessive drinking group than those in their control groups,and the prevalence of hypertriglyceridemia and hypertension were opposite. However, the changes of fasting glucose and body mass index were not consistent with those changes, and there was no difference of prevalence of the metabolic syndrome between these groups. Conclusion The influence of drinking on the multiple metabolic disorders is complicated, on one hand, drinking might increase blood pressure and serum triglyceride concentration, on the other hand, it could reduce the prevalence of abdominal obesity, blood glucose disorders, and low HDL-C concentration.
出处
《肝脏》
2005年第1期11-15,共5页
Chinese Hepatology
