摘要
用低硒（Ｓｅ）、低维生素Ｅ（ＶＥ）的克山病病区粮喂养大鼠１１周，血浆和心肌白三烯（ＬＴＣ４）水平上升，心肌自由基净含量增加，血清和心肌脂质过氧化物（ＬＰＯ）浓度增高，而全血和心肌谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活力下降；补Ｓｅ、ＶＥ或Ｓｅ＋ＶＥ可明显降低大鼠ＬＴＣ４水平及自由基和ＬＰＯ浓度，除补ＶＥ组外均可提高ＧＳＨ－Ｐｘ活力。提示：食物中Ｓｅ与ＶＥ不足影响花生四烯酸代谢中脂氧合酶的活力及Ｓｅ与ＶＥ不足生成的过量自由基和ＬＰＯ促进ＬＴＣ４合成，可能参与克山病缺血缺氧性心肌损害的发生发展过程．
reduction in the glutathion peroxidase (GSH-PX) activity of
theblood and myocardium accompanied with increases of leukotriene C4 (LTC4),free radical and
lipid peroxides (LPO) concentrations of the plasma andmyocardium was observed in Wistar rats
maintained on low selenium(Se)and vitamin E (VE)diets from Kehsan disease endemic area for
11 weeks。The production of LTC4,free radical and LPO were decreased in rats ma-intained on
Se or/and VE supplemented diets, and GSH-Px activity wasincreased except for VE
supplemented group. These results suggested thatthe dietary deficiency of Se and VE might
alter arachidonic acid metabo-lism and take part in the development of Keshan disease
myocardical ne-crosis by changing the activity of lipoxygenase.
出处
《营养学报》
CAS
CSCD
北大核心
1994年第4期367-370,共4页
Acta Nutrimenta Sinica
基金
由国家"八五"攻关项目
关键词
硒
维生素E
白三烯
克山病
selenium vitamin E
leukotriene C4 keshan disease
