摘要
本实验研究了硒（Ｓｅ）和维生素Ｅ（ＶＥ）对大鼠血液流变学、血栓素（ＴＸＡ２）、前列环素（ＰＧＩ２）的影响。结果表明，饲以低Ｓｅ和低ＶＥ粮大鼠红细胞变形性、ＰＧＩ２水平降低，红细胞压积、红细胞聚集性、红细胞聚集指数、ＴＸＡ２水平、ＴＸＡ２／ＰＧＩ２比值升高，谷胱甘肽过氧化物酶和超氧化物歧化酶活力降低，脂质过氧化物含量增高。补充Ｓｅ或ＶＥ及Ｓｅ＋ＶＥ对纠正上述变化有相似而又不尽相同的效果，以联合补充效果好。结果提示，Ｓｅ和ＶＥ不足可能通过两个途径：（１）间接途径─—花生四烯酸代谢产物ＴＸＡ２、ＰＧＩｅ水平；（２）直接途径──Ｓｐｅｃｔｒｉｎ与红细胞变形性，影响血液流变性能及微循环功能，可能参与缺血缺氧性心肌损害的发病环节。
he effect of selenium (Se)
and vitamin E(VB)deficiencies on hemor一 heology,thromboxane(TXA2)and
prostacvclin(PGI2)concentrations of rats were studied.The results showed that
hematocrit,erythrocyte aggregation,erythrocyte aggregation index,TXA2 TXA2/PGI2 and lipid
peroxide concen- trations of Wistar rats fed with grain from Keshen Disease area were signi-
ficantly higher than those of the control,but erythrocyte modification,PGI2 level,GSH-px and
Cu。Zn-SOD activity were decreased.There were some improvement by adding Se or/and VE,If
Se and VE were supplemented toge- ther, the result was better. The dietary deficiencies of Se
and VEH might have effect on hemorheologic clianges through two ways:(1)adjusting TXA2 and
PGI2 levels;(2)modifying spectrin and ervthrocyte functions.This mechanism might take part in
the pathogenesis of ischaemic myocardial da一mages。
出处
《营养学报》
CAS
CSCD
北大核心
1995年第1期22-26,共5页
Acta Nutrimenta Sinica
基金
国家"八五"攻关课题
关键词
硒
维生素E
血液流变学
微循环
selenium vitaminE
microcirculation hemorheology
