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实时在位测定大鼠脑组织优化散射系数(μ's)的技术研究 被引量：12

In Vivo and Real Time Measurement of Rat Brain Reduced Scattering Coefficient(μ's)
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摘要 目的:测试大鼠活体脑组织优化散射系数(reducedscatteringcoefficient:μ’s)。材料与方法:利用稳定态光纤光谱仪对大鼠脑组织的优化散射系数进行了系统研究,基本方法是利用悬乳液(Intralipid)和模拟胶(Phantom)模拟实验的μ’s经验公式得到大鼠脑组织在近红外波段(650nm～850nm)μ’s谱。结果:获得了大鼠脑白质和脑灰质的优化散射系数活体在位测量经验公式。结论:首次获得活体在位大鼠脑组织μ’s谱规律。 Objective: Reduced scattering coefficient(μ's)measurement of living ra t brain tissue.Materials and methods: A specific designed fiber optical spectrum system was applied to measure the optical parameters in rat brain tissue. The r educed scattering coefficient(μ's) spectrum was obtained from the responding em pirical formula which can be fitted through intralipid and phantom experiment. R esults:measurements.The empirical formula of reduce scattering coefficient(μ' s) in gray matter and white matter of rat brain tissue was obtained from the sys temic statistic analysis. Conclusion: the μ's NIR spectrum of live rat brain ti ssue was obtain for the first time.
作者 钱志余 顾月清 刘汉莉
机构地区 南京航空航天大学生物医学工程系 德州大学阿灵顿分校生物医学工程系 中国药科大学生命科学与技术学院
出处 《中国医学物理学杂志》 CSCD 2005年第2期463-465,共3页 Chinese Journal of Medical Physics
基金 AmericaNationalInstituteofNeurologicalDisordersandStrokeGrantNo.NS40874-02
关键词 脑白质 吸收系数 优化散射系数 光谱仪 brain white matter absorption coefficient reduced scattering coeffi cient spectrometer
分类号 TQ63 [化学工程—精细化工]
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参考文献9

  • 1L.Reynolds, C.Johnson and A.Ishimaru, Diffuse reflectance from a finite blood medium: applications to the modeling of fiber optical catheters[J]. Appl. Opt., 1976,15:2059-2067.
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  • 6钱志余,陈仁文,顾月清,Cole A.Giller,刘汉莉.生物组织光学参数:优化散射系数(μ′_s)的实时在位测定[J].南京航空航天大学学报,2004,36(3):369-372. 被引量：14
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  • 8Zhiyu Qian, Sunder S. Victor, Yueqing Gu, etc. "Look-Ahead Distance" of a fiber probe used to assist neurosurgery:Phantom and Monte Carlo study[J]. OPTICS EXPRESS, 2003,11(16):1844-1856.
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二级参考文献9

  • 1Cheong W F, Prahl S A, Welch A J. A review of the optical properties of biological tissues[J]. IEEE J Quantum Electron, 1990, 26:2166～2185.
  • 2Reynolds L, Johnson C, Ishimaru A. Diffuse ref-lectance from a finite blood medium: applications to the modeling of fiber optical catheters[J]. Appl Opt,1976,15: 2059～2067.
  • 3Groenhuis R A J, Ferwerda H A, Ten Bosch J J. Scattering and absorption of turbid materials determined from reflection measurements.1:theory[J]. Appl Opt,1983, 22:2456～2462.
  • 4Steinake J M, Shepherd A P. Diffusion model of the optical absorbance of whole blood[J]. J Opt Soc Am,1988,A5:813～822.
  • 5Schmitt J J M, Zhou G X, Walker E C. Multilayer model of photon diffusion in skin[J]. J Opt Soc Am,1990, A7:2141～2153.
  • 6Qian Zhiyu, Victor S S, Gu Yueqing, et al. "Look-ahead distance" of a fiber probe used to assist neurosurgery: phantom and Monte Carlo study[J]. OPTICS EXPRESS, 2003,11(16):1845～1857.
  • 7Matcher S J, Cope M, Delpy D T. In vivo measur-ements of the wavelength dependence of tissue-scattering coefficients between 760 and 900 nm measured with time-resolved spectroscopy[J]. Appl Opt, 1997,36:386～396.
  • 8Pham T H, Bevilacqua F, Spott T, et al. Quanti-fying the absorption and reduced scattering coefficient of tissuelike turbid media over a broad spectral range with noncontace Fourier-transform hyperspectral imaging[J]. Appl Opt,2000,34:6487～6497.
  • 9Nichols M G, Hull E L, Foster T H. Design and testing of a white-light,steady-state diffuse reflectance spectrometer for determination of optical properties of highly scattering systems[J]. Appl Opt,1997, 36:93～103.

共引文献13

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二级引证文献30

中国医学物理学杂志
2005年 第2期

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