摘要
从中华猕猴桃果中提取粗多糖FP,FP经阴离子交换层析得到多糖FP1和FP2。采用S180移植瘤模型,考察FP、FP1和FP2的抗肿瘤作用。结果表明,多糖FP2具有显著的抗肿瘤活性,在150mg/kg的给药剂量下,对S180肿瘤细胞的抑制率达到54.2%。凝胶过滤层析表明,FP2为单一的组分。纸层析表明,FP2含有D-葡萄糖、D-甘露糖和D-半乳糖。
A raw fruit polysaccharide (FP) was isolated from Chinensis Actinidia Planch. By using ion exchange chromatography, FP was separated into two parts, FP1 and FP2. The inhibitory effects of FP, FP1 and FP2 on the transplanted tumor cells of Sarcinoma 180 (S180) in mice were tested. The results showed that with the dosage of 150mg/kg FP2 could evidently reduce the tumor weight of S180, and the inhibitory rate reached 54.2%. The homogeneity of FP2 was proved by size exclusion chromatography. Paper chromatography showed that FP2 contained D-glucose, D-mannose and D-galactose.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2005年第2期213-215,共3页
Food Science
基金
国家中医药管理局科研项目(2000-J-P-41)
关键词
中华猕猴桃
多糖
纯化
抗肿瘤
Chinesis Actinidia Planch
polysaccharide
purification
anti-tumor activity
