摘要
检测了抗瘤iRNA及S-TF与化疗药物治疗46例肿瘤病人后外周血LT、T细胞亚群及IFN-γ水平变化。结果发现:1.肿瘤病人的LT、T细胞亚群及IFN-γ水平均明显低于正常人,且IFN-γ与LT及T_4相关显著。2.化疗前后各免疫指标均无明显变化,但免疗及免疫化疗后肿瘤病人的LT、T_3、T_4、T_4/T_8及IFN-γ均较治疗前显著增加,且LT、T_4及IFN-γ明显高于化疗组。结果表明,肿瘤对宿主存在着免疫抑制,抗瘤iRNA及S-TF不仅可减轻肿瘤宿主的免疫抑制,而且与化疗联用,还可能具有协同抗瘤作用。
Lymphocytes transformation (LT), T cell subsets and IFN-γ levels were measured in the tumor patients treated with antitumor iRNA, S-TF and chemotherapy. The results showed that (1) the LT, T cell subsets and IFN-γ of the tumor patients were significantly lower than those of normal controls, and the T4 and LT were significantly correlated with IFN-γ in the patients and controls, (2) both before and after chemotherapy there were no apparent changes in the T cell immune indexes, but the LT, T3, T4, T4/T8 and IFN-γ after immunotherapy and immunochemo-therapy were significantly improved when compared to those data before the therapy. Moreover, the LT, T4 and IFN-γ in immunochemotherapy were apparently superior to chemotherapy. The results suggested that (1) the host immunosuppressing action was produced by tumor, (2) the antitumor iRNA and S-TF may play an antitumor effect by reducing the immunosuppressing action of tumor to the host and by being in cooperation with chemotherapeutic agents.
出处
《天津医药》
CAS
1994年第4期205-207,共3页
Tianjin Medical Journal
关键词
免疫核糖核酸
肿瘤
药物疗法
T细胞
anti immune RNA specific transfer factor chemotherapy cellular immune neoplasms
