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含消炎痛VCu200与VCu200临床比较性研究 被引量:8

A Randomized Study of VCu200 with or without Indomethacin
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摘要 对1000例含消炎痛VCu200与1000例对照组进行比较性研究。在24个月末,每100妇女净累积续用率分别为83.20与83.36,其中妊娠率分别为2.20与1.41(P>0.05)。脱落率在12与18个月时药环组较对照组高(P<0.05),24个月时分别为8.81/100与6.62/100妇女,无显著性差别,但相对来讲药环组还是较对照组高。因症取出率对照组高于药环组(P<0.05)。主要原因是出血,具体表现在经量增多,经期延长与点滴出血。这三种现象两组之间P值均<0.01,药环与对照环避孕效果相似而药环基本解决了用IUD的主要副反应出血问题。本文分析脱落率较高的可能原因,并对药环的装置进行了改进,用改进后的药环观察一年,脱落率有所下降。 This paper reported a randomizod comparative study of 2000 cases of VCn200 with or without indomethacin.The cumulative continuation net rate per 100 women at the end of 2 years was 83.20% and 83.36%,respectively.The pregnancy rate of two IUDs were 2.20% and 1.41% respeetively(P>0.05)and the expulsion rate was higher in medicaled IUD at 12 and 18 month(P<0.05).The statistic difference oval not significant(P>0.05)at 24 month,although the expulsion rate was comparatively higher in medicaled IUD.The termination rate related to IUD use was higher in VCu200 (P<0.05),mainly due to side effects such as prolonged menstrual period,inerease of menstrual flow and vaginal spotting.There were highly significant statistic difforenoes(P<0.01)in these three conditions between two IUDs.Finally,the possible causes of higher expulsion rate of medicated IUD were discussed.Improvement of IUD was introduced and followed by decreasing expulsion rate after one year
出处 《生殖与避孕》 CAS CSCD 北大核心 1994年第3期209-214,共6页 Reproduction and Contraception
关键词 消炎痛 VCU200 药理 药物副作用 VCu200,Indomethacin,Effect,Side effects
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  • 1S. El-sahwi,M. Toppozada,M. Kamel,S. Gaweesh,W. Riad,I. Ibrahim,H. El-sabbagh. Prostaglandins and cellular reaction in uterine flushings. I. Effect of IUD insertion[J] 1987,Advances in Contraception(4):291~302

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