摘要
本文观察了５／６肾切除慢性肾衰大鼠血液和残肾组织氧自由基有关指标。发现氧自由基在残肾的毁损中起重要作用，抗氧化剂维生素Ｅ能保护残肾。在正常和慢性肾衰情况下，血浆脂质过氧化物和维生素Ｅ浓度及红细胞超氧化物歧化酶活力与残肾组织的相应指标相关非常显著。
The correlation of oxygen free radical items between blood and kidney of 5/6 nephrectomy-induced chronic renal failure rats was studied. It was found that oxygen free radicals played an important role in the impairment of remnant kidney, and antioxidant vitamin E could protect remnant kidney from the impairment caused by oxygen free radicals,and that.,both in normal and chronic renal failure conditions ,plasma lipid peroxides and vitamin E concentration and superoxide dismutase activity of red blood cells correlated very well with corresponding items of remnant kidney. These results suggested that blood oxygen free radical items could reflect renal oxygen free radical metabolic status in chronic renal failure patients.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1994年第5期344-347,共4页
Journal of Third Military Medical University
基金
全军青年基金
关键词
肾功能衰竭
慢性
大鼠
血液
肾
自由基
kidney failure, chronic
rat
blood
kidney
free radicals
