摘要
在２０％ＦｅＣｌ３造成大鼠颈总动脉血栓形成的模型上，分别预防（血栓形成前）和治疗（血栓形成后）应用合成的纤维蛋白（原）降解肽片段，肽６Ａ（５０μｍｏｌ／ｋｇ）和ＲＧＤＳ（１０μｍｏｌ／ｋｇ）或联合肽６Ａ（２５μｍｏｌ／ｋｇ）与ＲＧＤＳ（５μｍｏｌ／ｋｇ）静脉滴注，明显抑制动物的血栓形成，使血浆和血管组织ｃＧＭＰ含量明显增加，肽６Ａ还明显降低血浆纤维蛋白原含量。本工作为肽６Ａ和ＲＧＤＳ作为新型血管再通剂提供了实验依据。
n the model of rat carotid thrombosis induced
by 20% FeCl3,fibrin (ogen) degradation product peptide 6A (50 μ
mol/kg),RGDS (10μmol/kg),and peptide 6A (25μmol/kg)plus RGDS(5 μ
mol/ kg)were intravenously infused for prevention(before
thrombosis)and treatment(after thrombosis)respectively.It was found
that the thrombosis was significantly suppressed,plasma and vascular
cGMP content was obviously increased,and that peptide 6A markedly
lowered plasma fibrinogen content.The results afford experimental
evidence of peptide 6A and RGDS as novel agent of vascular
recanaliza-tion
出处
《北京医科大学学报》
CSCD
1994年第1期17-19,共3页
Journal of Peking University(Health Sciences)
关键词
肽6A
RGDS肽
纤维蛋白原
血栓形成
Peptide 6A
RGDS peptide
Fibrinogen
Thrombosis
Vascular recanalization
