摘要
３，４，５－三甲氧苯甲醛是制ＴＭＰ的关键中间体，用苯酚先磺化再溴化，再经甲氧基化、甲酰化、甲基化４步反应合成。每步产率分别为７７．７％，７６．０％，４１．０％和９３．０％，总收率为２２．５％。对２，６－二甲氧基苯酚的Ｖｉｌｓｍｅｉｅｒ－Ｈａａｃｋ甲酰化反应，Ｄｕｆｆ反应以及Ｒｅｉｍｅｒ－Ｔｉｅｍａｎｎ反应等可能的甲酰化方法进行了研究。
MeO)_3 C_6H_2CHO,useful as an inteimediate for pharmacenticals,was prepared in 4 steps starting from phenol,bromination of p-phenol sulfonic acid,and then methoxylation of the resulting 2,6-dibromophenol to form 2,6-dimethoxyp henol,fromylation of which gives 3,4,5-(MeO)_2(OH)C_6H_2CHO.After further methylation with Me_2SO_4 gives 3,4,5-(MeO)_3C_6H_2CHO.The yields are 77.7 % , 76.41% and 93%respectively .
出处
《北京师范大学学报（自然科学版）》
CAS
CSCD
1994年第1期115-118,共4页
Journal of Beijing Normal University(Natural Science)
关键词
三甲氧基
苯甲醛
合成
苯酚
phenol
3,4,5-trimethoxybenzaldehyde
Vilsmeier-Haack reaction
Duff reaction
Reimer-Tiemann reaction
