摘要
背景与目的:杜仲属于可用于保健食品的中药,但是其安全性毒理学评价的资料相对缺乏,对其安全性进行评价,以便为杜仲的综合利用提供依据。材料与方法:运用急性毒性试验、细胞毒性试验、遗传毒性试验对杜仲进行了较系统的安全性评价。结果:杜仲的LD50为160.0 g/kg;对CHO和CHL细胞的IC50均为109.38 mg/ml,并且在该剂量之下为阴性结果。结论:杜仲属无毒物,在较高剂量下对CHO和CHL细胞均表现出一定的毒性;本实验条件下无细胞染色体畸变的遗传毒性。
BACKGROUND & AIM: Although Duzhong was listed on the function food roll, there was lack of data of systematic toxic/safety evaluation experiments. MATERIAL AND METHODS: Safety evaluation experiment was done using acute toxicity experiment, cell toxicity experiment and genetic toxicity experiment . RESULTS: CHL and CHO were 109.38 mg/ml; it was negative in toxicity. CONCLUSION: It was found that Du zhong was a non-toxic substance and was negative in genetic toxicity, although it had some toxic effect on the CHO and CHL cell at higher dose levels.
出处
《癌变·畸变·突变》
CAS
CSCD
2004年第6期355-358,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
国家科技攻关计划课题(No.2001BA804A06)
关键词
杜仲
急性毒性
遗传毒性
Duzhong
acute toxicity
genetic toxicity
