摘要
目的 研究氯沙坦对原发性高血压(EH)患者血管内皮功能的影响.方法 分析应用氯沙坦前后EH患者血压、ET(血浆内皮素)及NO(一氧化氮)的变化.结果 EH患者血浆ET升高(P<0.01)、NO降低(P<0.01).应用氯沙坦后,EH患者血压显著下降(P<0.01)、ET明显降低(P<0.01),NO明显升高(P<0.01).结论 氯沙坦可有效降压,并能逆转EH患者血管内皮功能紊乱.
ve To study the effect of Losartan on endothelial function in patients with essential hy-pertension (EH) .Methods Blood pressure, ET, and NO value were determined and analysed in 30 EH patients be-fore and after Losartan had been used for 4 weeks.Results The plasma ET was higher than that of the controlgroup(P < 0. 01) and NO was lower than that of the latter(P < 0. 01) .Both of blood pressure and plasma ET werereduced greatly (P < 0. 01), while serum NO was increased significantly (P < 0. 01) after Losartan had been used for 4weeks. Conclusion Losartan may be effective in the treatment of hypertension and may reverse the disturbence ofimpaired endothelial function in EH patients.
