摘要
促肾上腺皮质激素(ACTH)可提高海马内 r-氨基丁酸(GABA)含量和痛阈,降低淋巴细胞转化指数和白细胞介素Ⅱ(IL-Ⅱ)的产生。GABA 合成酶抑制剂异烟肼(INH)和 GABA 受体阻断剂印防(?)毒素(PTX)可对抗 ACTH 升高痛阈和降低淋巴细胞转化指数和 IL-Ⅱ产生的作用;而免疫抑制剂环孢素 A(CyA)则可削弱 ACTH 镇痛及其提高海马内 GABA 含量的效应。结果提示 ACTH可通过海马 GABA 增多而镇痛,ACTH 对细胞免疫的抑制作用可能与脑内 GABA 有关,细胞免疫可能参与 GABA 含量的调节,GABA 合成及其受体在下述作用中起着重要的介导作用。
After intraperitoneal injection of ACTH,the content of GABA in hippoca-mpus and the pain threshold were increased.This effect could be decreasedby cycrosporin.ACTH decreased SI of MSBT and production of IL-Ⅱ,andthis suppression could be reversed by GABA synthesis inhibitor isoniazid,orGABA receptor blocker picrotoxin.These results suggest that:the analgesiceffect of ACTH is related with the increase of GABA content in hippocampus,and cell immunity could be involved the regulation of GABA content in thebrain regions.ACTH inhibited the effect of cell immunity,and this effect rela-ted to GABA content.Above effect is at least partly mediated by GABAsynthesis and GABA receptor.
出处
《针刺研究》
CAS
CSCD
1993年第1期58-63,共6页
Acupuncture Research
