摘要
早在一百多年前,人们就已经认识高压氧(0HP)对中枢神经系统具有毒性作用,可引起惊厥反应。然而,关于OHP惊厥的发病机理以及有效地防治OHP惊厥等问题。
This paper reports the effect of acupuncturing 'Renzhong' (GV26) and 'Chengjiang' (GV24) points on OHP-induced convulsion in mice. The results are as follows: 1. Convulsion induced by 6 ATA OHP were accompanied with a decrease in the brain GABA concentration. 2. When electro-acupuncture was applied for 15 minutes prior to exposure to hyperoxic chamber, the latence of convulsions was lengthened and the symptomes of seizures were alleviated. Besides, the brain GABA concentration was also elevated remarkably. 3. Administration of vitamin B_6 enhanced the effect of acupuncture on convulsions and icreared brain GABA concentration. 4. The latence of convulsions was well correlated with the GABA concentration of the brain (r = 0.9867). The above results indicate that acupuncture may elevate endogenous GABA levels in the brain and prevent the hyperbaric-oxygen-induced the decrease in the brain GABA content. Therefore. It is of protective effect against oxygen convulsions. Vitamin B6 may facilitate the effect of acupuncture by imprpving the GABA metabolism in the brain. In short, the effect of acupuncture against oxygen convulsions may be closely related to the increase in the brain GABA levels. OHP. high oxvgen pressure
出处
《针刺研究》
CAS
CSCD
1992年第2期104-109,共6页
Acupuncture Research
