摘要
本文所涉及的“四项抗感染实验研究”是发生在十年前的事件 ,其中心内容是部分烧伤医生和科研工作者试图通过几个非系列性的试验研究从烧伤创面感染来否定湿润烧伤膏的药效作用。事件至今虽有十年了 ,但湿润烧伤膏的疗效已被公认。据统计 ,每年全国各家医院成功应用湿润烧伤膏治疗大面积烧伤病人超过 35万余例。大量严重烧伤病人治愈成功的事实以及大量临床和基础研究试验也都证明了这几项研究的片面性和错误结论。这四项研究从设计思路、研究目标等方面不仅带有主观意愿 ,而且其研究方法和结果明显存在主观控制实验结果的嫌疑 ,缺乏严谨的科学态度。为了避免继续在社会和学术界产生影响 ,现在对这四项错误实验进行剖析 ,其目的是提醒和教育广大医疗和研究人员 ,在今后的研究工作中不能像所剖析的作者那样 ,要严格按科学实验的基本原则和规律开展工作 ,避免给患者带来更大的伤害和遗憾。
The matter about “Four Anti-infection Experimental Studies' referred in this article occurred ten years ago. In these studies, some burn doctors and researchers tried to negate the pharmacodynamic action of MEBO (Moist Exposed Burn Ointment) for the wound surface infection through several non-series experiments. The therapeutic effect of MEBO has been generally accepted after the ten years. According to statistics, there is more than 350 thousands of massive burn patients treated by MEBT/MEBO in different hospitals national wide annually. The successful treatment of tons of serious burn patients by MEBT/MEBO and the large amount of clinical and basic research all proved the one-sidedness and false conclusions of these studies. The design and goal of these studies had obvious subjective will; more addition, the research methods and results were short of rigorous scientific attitude with suspicion of subjective controlling of the results and conclusions. In order to avoid the continuous false influence in society and academic circles, we analyzed these studies, the purpose is to remind and educate the doctors, researchers and medical stuffs to carry out work and study strictly following the basic principle and rule of scientific experiments. More addition, this article is tried to avoid larger damages and regrets of the patients. The related information is as the follows: In the year of 1993 to 1994, the four papers: Comparision of therapeutic value of various topical agents in pseudomonas aeruginosa infection; An experimental study by GUO Zhen-rong, SHENG Zhi-yong; Experimental study on the anti-infection effect of MEBO by YANG Yong, GE Sheng-de, et al; The influence of the microbiological effect and immune function for MEBO in treating burn area by CHEN Bi, BAI Gang, et al; The influence of MEBO on burnt rat IL-2 and some clinical problems byYAN Ru-yun,ZHU Ming et al were continuously published in the Chinese Journal of Plastic Surgery. Clinical practices proved that these reports were incorrect. With the artful subjective design, the clinical pharmacology effect of MEBO promoting necrotic tissue liquefaction and the action mechanism on wound infection were turned into the wound infection through non-standard usages and/or non-suitable animal models. Thus, the non-scientific conclusions were obtained through non-scientific analytical method, which disobeyed many basic principles of experimental design. The purpose for today's analysis is to comment on the 'true and false' through the combination of science and history with the scientific attitude. Those false study conclusions shouldn't be remained in medical database as refs for ever. Practice is the only standard to test the truth. Their results did neither withstand the scientific research repetition, nor the confirmation of clinical practices. Our purpose is to let the true scientific research achievement benefit human beings and let the non-scientific or pseudoscientific false experiments expose to the public, and then eliminate their influence on both basic research and clinical practice. In order to clarify the 10-year's influence by these studies, the senior experimental study group was set up by the Chinese Burn Association of the Integration of Traditional and Western Medicine (CBAIM), the false design and protocol was analyzed in details to let all the researchers, clinical faculties and stuffs, and medical educators to further understand the mistakes of these four experimental studies; to identify clearly the importance of the correct study design and perform; to avoid the similar mistakes, to increase the academic study level. It should be emphasized that the 'Malpractice Identification Regulation' was issued in Aug. of 2003 in China, which promotes the burn medical faculties, stuffs and researchers to truly and objectively introduce advanced medical techniques to patients; to specify the doctors' medical treatment standards and researchers' study levels by law. The common mistake of the four anti-infectious experiment designs is: th
出处
《中国烧伤创疡杂志》
2005年第1期1-13,共13页
The Chinese Journal of Burns Wounds & Surface Ulcers
关键词
烧伤创面
感染
实验研究
剖析
Burn wound surface
Infection
Experimental Study
Analysis
