摘要
目的 分析血清低氧应激肽的特征和健康成年人急进高原前后血清低氧应激肽的改变 ,探讨其在高原病治疗和预后中的作用。方法 采用质谱和核磁波谱方法鉴定高原病患者体内存在特征性的应激肽 ,采集 40例高原世居健康者为对照 ,40例健康成年人急进高原前 ,急进高原后 2 4h ,72h ,1周后血清 ,用化学显色试剂对应激肽含量进行测定。结果 40例世居对照组应激肽含量为 72 .9± 9.8mg/L ,健康成年人急进高原前、急进高原后 2 4h ,72h ,1周应激肽含量分别为 73 .5± 11.7mg/L ,90 .8± 10 .3mg/L ,91.7± 10 .1mg/L ,82 .8± 9.5mg/L ,健康成年人急进高原前与急进高原后 2 4h及72h之间有显著性差异 (P <0 .0 5 ) ,急进高原后 2 4h人群与健康世居组之间有显著性差异 (P <0 .0 5 ) ,急进高原后 1周与急进高原后 2 4h之间有显著性差异 (P <0 .0 5 )。结论 应激肽作为一种特殊的应激蛋白 ,在急进高原前后有较大的改变 ,具有一定的价值。
Objective To find out the change of the hypoxia stress peptide(HSP)in the enter mountain rapidly man and the character of HSP.Methods Collection the serum of the health and the entering mountain rapidly man,detect the HSP with nuclear magnetic resonance spectroscopy H.Results The content of the HSP of the the inhabit man and entering mountain rapidly man in the time of before 24 h,3day,7day of 72.9±9.8mg/L,73.5±11.7mg/L,90.8±10.3mg/L?91.7±10.1mg/L,82.8±9.5mg/L. Conclusions The HSP was raised in the entering mountain rapidly man,HSP would be reference value in judgement the effect of the treatment and important to the patient of the mountain sickness.
出处
《四川医学》
CAS
2005年第2期140-143,共4页
Sichuan Medical Journal
基金
四川省基金项目重点课题 (0 0 0 2 2 1 )
关键词
急进高原
低氧
应激肽
enter mountain rapidly
low oxgen
hypoxia stress peptide
nuclear magnetic resonance spectroscopy H
