摘要
采用改良的乳化冷冻凝聚法制备As2 O3磁性纳米微球 ,用能谱仪、透射电镜、原子荧光分光光度计、原子吸收分光光度计、图像分析仪和动力渗析系统等进行特性研究 .结果显示所制备的As2 O3磁性纳米微球近似球形 ,粒径为 ( 1 90± 5 0 )nm ,其中含As2 O3( 0 65 989± 0 42 ) μg/mg ,锰锌铁氧体磁性纳米粒子 ( 69 5 70 2 7± 0 36) μg/mg ,缓释性好 .用作微球载体的Mn0 4Zn0 6Fe2 O4的居里温度为 1 0 5 40 7℃ ,其不同浓度的磁流体在高频交变磁场下可升温至 43～ 47℃并保持不变 .实验结果表明 ,采用改良的乳化冷冻凝聚法可以成功制备As2 O3磁性纳米微球 ,并为载药磁性微球及磁流体热疗的研究提供了理论及实验依据 .
Magnetic nano-microspheres containing As2O3 are prepared by a modified cold-condensation method. Energy dispersive spectrometer, transmission electron microscopy (TEM), atomic fluorescence spectrophotometry, atomic absorption spectrometry, computer color magic image analysis system and dynamic dialysis system are used to characterize the product. It is shown that magnetic nano-microspheres containing As2O3 are spherical with the diameter of (190 ± 50) nm. As2O3content is (0.659 89 ± 0.42) μg/mg and Mn-Zn ferrite (69.57027 ± 0.36) μg/mg in nano-microspheres. The magnetic particles of microsphere carrier have a Tc of 105.407°C. The temperature of magnetic fluids with different concentration can be raised and maintained at 43-47°C under the effect of high frequency alternating magnetic field. Experimental results show that magnetic nano-microspheres containing As2O3 can be successfully prepared by this modified cold-condensation method. The result provides a theoretical and practical basis for further study of magnetic microspheres containing medicine and magnetic fluid hyperthermia.
出处
《东南大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2004年第6期797-801,共5页
Journal of Southeast University：Natural Science Edition
基金
国家自然科学基金资助项目 (3 0 3 7183 0 )
国家高技术研究发展计划 (863计划 )资助项目 (2 0 0 2AA3 0 2 2 0 7)
江苏省自然科学基金资助项目 (BK2 0 0 10 0 3 )
江苏省中医药
中西医结合重点资助项目 (H0 2 7)
东南大学科学基金资助项目 (92 2 3 0 0 1162 ) .
