摘要
目的 探讨胃溃疡患者心理社会因素 ,尤其是情绪因素与溃疡的关系。方法 对 89例胃溃疡患者和5 0例正常人分别进行人格、述情、社会支持、生活事件等量表评定以及血小板 5 - HT检查。结果 1溃疡组的人格特征中疑病、抑郁、精神衰弱、精神分裂、癔症五个因子均分高于正常组 ;2溃疡组汉密尔顿抑郁、焦虑量表(HAMA、HAMD)以及述情量表 (TAS)得分高于正常组 ;3溃疡组的血小板 5 - HT浓度明显低于正常对照组 (P<0 .0 5 ) ;4幽门螺旋杆菌 (Hp)感染阴性的溃疡患者其溃疡面积与 HAMA得分及 TAS得分呈正相关。结论 1个性和述情方式与胃溃疡的发生存在着某种联系 ;2可能存在着分别与 Hp感染和与负性情绪以及述情方式密切相关的两种胃溃疡类型。
Objective To scrutinize the association of psychosocial factors especially emotional factors with peptic ulcer. Methods Eighty-nine peptic ulcer patients and 50 normal controls were investigated by means of questionnaires for personality, alexithymia, social support, life events, and their platelet 5-HT levels were determined. Results By comparison with normal controls, the peptic ulcer patients had:① higher scores on the subscales such as Hs, D, Pt, Sc and Hy of personality; ② Higher scores on HAMA, HAMD and Toronto alexithymia scale(TAS); ③ Significantly lower platelet 5-HT concentration. And in the ulcer patients who were not infected with HP (called HP negative), the area of their ulcer was found to have a positive correlation with HAMA and TAS scores (r=0 74,P<0 01;r=0 45,P<0 05). Conclusion ①There was a correlation between the onset of peptic ulcer and personality or manner of emotional expression. ② There may be two subtypes of ulcer patients: one of it may be due to HP infection and the other may be more closely associated with negative emotion and manner of emotional expression; for the latter one, anxiolytics deserve to be included in the routine treatments.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2004年第6期815-817,共3页
Journal of Sichuan University(Medical Sciences)
基金
四川省卫生厅科研基金 ( 0 10 0 0 1)资助
