摘要
目的 :进一步研究心理社会因素尤其情绪因素与消化性溃疡的关系 ,并初步探讨消化性溃疡患者的神经生物学机制。方法 :对符合条件的 34名消化性溃疡患者和 30名正常人分别进行一系列的量表评定、多导睡眠图及血小板五羟色胺检查 ,采用t检验或方差分析、spearson相关检验及多元逐步回归对资料进行统计分析。结果 :1 消化性溃疡组的MMPI的Hs (疑病 )、D (抑郁 )、Pt (精神衰弱 )、Sc (精神分裂症 )、Hy (癔症 )五个因子均分高于正常组 ;HAMA、HAMD及TAS的得分 ,溃疡组高于正常组。 2 与正常组比较 ,溃疡组睡眠维持率低、觉睡比高 ;两组的第一个REM睡眠时间及百分比有差异。 3 消化性溃疡组的平均血小板 5 -HT浓度低于正常对照组 ,差异接近显著性水平。 4 消化性溃疡患者血小板 5 -HT浓度与HAMA评分呈正相关。 5 溃疡面积与HAMA得分及TAS得分呈正相关。结论 :1 消化性溃疡在病因上可能存在不同的亚型。在心理因素中 ,内在个性可能起着更关键的作用。 2 抗焦虑、抑郁治疗是治疗消化性溃疡的重要部分。 3
Objective: To evaluate the psychosocial factors in peptic ulcer,and to make a preliminary study on the neurobiological aspects of peptic ulcer.Methods:Thirty-four patients with peptic ulcer and 30 normal control subjects were studied.Using a series scales to assess psychosocial factors;Polysomnography and high-performance liquid chromatography(HPLC-EC) assays of platelet 5-HT were performed before receiving medications.Results:1 Patients with peptic ulcer had statistically significantly higher scores in scales Hs,D,Hy,Pt,and Sc of MMPI,and in the three mood scales (HAMA,HAMD,TAS)compared with that of the controls.2 Patients with peptic ulcer exhibited sleep maintaneuce disturbance,i.e.increased awakening time and number,diminished sleep maintenance. Increased First rapid eye movement(REM)sleep time and the percentage were also noted. 3 Platelet 5-HT level of patients with peptic ulcer were lower compared with that of the controls. 4 The lever of platelet 5-HT was positively correlated with scores on HAMA in peptic ulcer. 5 The area of ulcer was positively correlated with scores on scales HAMA and TAS. Conclusions:1 In etiology, peptic ulcer was probably divided into different subtypes. In psychosocial factors, the personality of patients with peptic ulcer maybe play an important role;2 Combining with antidepression and antianxiety might give help to the patient,with peptic ulcer;3 Patients with peptic ulcer exhibited the similar abnormality of sleep EEG and platelet 5-HT as depression, which showed peptic ulcer and depression may have relationship in neurobiological aspects.
出处
《华西医学》
CAS
2003年第2期187-189,共3页
West China Medical Journal
基金
四川省心身疾病多中心研究项目(0 2 0 0 62 )
