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度洛西汀的合成进展 被引量：11

Development in the Synthesis of Duloxetine
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摘要 介绍了近年来抗抑郁新药度洛西汀的各种合成方法 ,并评述了其优缺点。参考文献 13篇。 Synthesis methods for Duloxetine of antidepressant drug were reviewed and their advantages and disadvantages were described with 13 references.
作者 温新民 毛庆华 汤建 虞心红
机构地区 华东理工大学化学与制药学院
出处 《合成化学》 CAS CSCD 2004年第6期551-554,共4页 Chinese Journal of Synthetic Chemistry
关键词 度洛西汀 抗抑郁 合成 综述 Duloxetine antidepressant synthesis review
分类号 R914.5 [医药卫生—药物化学] O625.34 [理学—有机化学]
  • 相关文献

参考文献13

  • 1Bymaster Frank P,Dreshfield-Ahmad,Laura J,Threlkeld Penny G.Comparative Affinity of Duloxetine and Venlafaxine for Serotonin and Norepinephrine Transporters in Vitro and in Vivo,Human Serotonin Receptor Subtypes,and Other Neuronal Receptors[J].Neuropsycho
  • 2Ahmed Kamal G B,Ramesh Khanna R,Ramu and T.Krishnaji. Chemoenzymatic Synthesis of Duloxetine and Its Enantiomer:Lipase-catalyzed Resolution of 3-Hydroxy-3-(2-thienyl)propanenitrile[J].Tetrahedron Letters,2003,44(25):4783-4787.
  • 3Reichert,Dietmar,Almena Perea,et al.Preparation of N-methyl-3-hydroxy-3-(2-thienyl)propylamine via Novel Thiophene Deprivatives Containing Carbamate Groups as Intermediaties[P].WO 03 070 720,2003-08-28.
  • 4Borghese Alflo.Process for Preparing an Intermediate Useful for the Asymmetric Synthesis of Duloxetine[P].WO 03 062 219,2003-07-31.
  • 5Liu H,Hoff B H,Anthonsen T.Chemo-Enzymatic Synthesis of the Antidepressant Duloxetine and Its Enantiomer[J].Chirality,2000,12(1):26-29.
  • 6Wheeler W J,Kuo F J.An Asymmetric Synthesis of Duloxetine Hydrochloride, A Mixed Uptake Inhibitor of Serotonin and Norepinephrine,and It C-14 Labeled Isotopomers[J].Label Compd Radiopharm,1995,36(3):213-223.
  • 7Kirwin Jennifer L,Goren Jessical L. Duloxetine.An Antidepressant that Inhibits Both Norepinephrine and Serotonin Uptake[J].Formulary,2003,38(1):29-30.
  • 8Norton Peggy A,Zinner Norman R.Duloxetine Versus Placebo in the Treatment of Stress Urinary Incontinence[J].American Journal of Obsterics and Gynecology,2002,187(1):40-48.
  • 9Deeter J,Frazier J,Saten G,et al.Asymmetric Synthesis and Absolute Stereochemistry of LY248686[J].Tetrahedron Lett,1990,31(49):7101-7104.
  • 10Richard A,Berglund,Lafayette.Asymmetric Synthesis[P].US 5 362 886,1994-11-08.

共引文献5

同被引文献101

  • 1于振云.抗抑郁药物的生产发展与市场前景[J].医药化工,2005(1):20-27. 被引量：1
  • 2高丽梅,朱凤昌,宋丹青.盐酸度洛西汀的合成[J].中国新药杂志,2005,14(1):74-76. 被引量：10
  • 3David J.Goldstein,史妙.度洛西汀在糖尿病患者神经痛中的应用[J].中国疼痛医学杂志,2005,11(6):348-348. 被引量：4
  • 4赵贵财,徐刚,吴坚平,杨立荣.3-氯-1-(2-噻吩)-丙酮合成工艺的研究[J].化学反应工程与工艺,2006,22(2):176-180. 被引量：1
  • 5国效峰,赵靖平,陈晋东.度洛西汀：一种新型抗抑郁药[J].中国新药与临床杂志,2006,25(7):552-555. 被引量：89
  • 6ANATHEA B W, PETER K. Duloxetine hydrochloride [ J ]. Nat Rev, 2004,3 ( 11 ) :907 - 908.
  • 7FDA [ EB/OL]. http://www, fda. gov/cder/foi/label/2004/2173- 31b1/pdf,2004 09 29/2005 03 16.
  • 8GALABRESE F, MOLTENI R, MAJ P F ,et al. Chronic duloxetine dreatment induces specific changes in the expression of BDNF transcripts and in the subcellular localization of the neurotrophin protein[ J ]. Neuro Psycho Pharmacology , 2007,32 ( 11 ) : 2351 - 2359.
  • 9MIRZA N R,NIELSEN E O,TROELSEN K B. Serotonin transporter density and anxiolytic-like effects of antidepressants in mice [ J ]. Prog Neuropsychopharmacol Biol Psychiatry, 2007,31 ( 4 ) : 858 - 866.
  • 10WESTANMO A D, GAYKEN J, HAIGHT R. Duloxetine:a balanced and selective norepinephrine-and serotonin-reuptake inhibitor[ J ]. Am J Health Syst Pharm, 2005,62 ( 23 ) : 2481 - 2490.

引证文献11

二级引证文献117

合成化学
2004年 第6期

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