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抗癫痫新药奥卡西平的合成进展 被引量：3

Development in the Synthesis of New Antiepileptic Drug Oxcarbazepine
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摘要 综述了抗癫痫药奥卡西平的各种合成方法 ,并评价了其优缺点。参考文献 3 Synthesis methods for new antiepileptic drug Oxcarbazepine were reviewed and their advantages and disadvantages were described with 37 references.
作者 谢建伟 苏为科 许建帼
机构地区 浙江工业大学浙西分校科研所 浙江工业大学药学院
出处 《合成化学》 CAS CSCD 2004年第6期540-544,585,共6页 Chinese Journal of Synthetic Chemistry
基金 浙江省教育厅科研计划项目 ( 2 0 0 310 81)
关键词 奥卡西平 抗癫痫药 合成 综述 Oxcarbazepine antiepileptic drug synthesis review
分类号 R914.5 [医药卫生—药物化学] O626 [理学—有机化学]
  • 相关文献

参考文献37

  • 1Learmonth David A,Benes Jan.Synthesis,Anticonvulsant Properties and Pharmacokinetic Profile of Novel 10,11-Dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide Derivatives[J].European Journal of Medicinal Chemistry,2001,36(3):227-236.
  • 2Knell A,Monti D,Maciejewski M,et al.Catalytic dehydrogenation of 10,11-Dihydro-5H-dibenz-[b,f] azepine(iminodibenzyl) to 5H-dibenz[b,f]azepine(iminostilbene) over Potassium-promoted Iron Oxides:Effect of Steam, Potassium Promotion and Carbon Dioxide Treat
  • 3Knell A,Monti D,Maciejewski M.Catalytic Dehydrogenation of 10,11-Dihydro-5H-dibenz[b.f]-azepine(iminodibenzyl) to 5H-dibenz[b.f]azepine(iminostilbene) over Potassium-promoted Iron Oxides[J].Applied Catalysis, A: General,1995,121(1):139-158.
  • 4Miquet Jean-Marie,Boireau Alain,et al.The Use of Carbamazepine and Oxcarbazepine and Their Non-toxic Salts in Medicaments for the Treatment of Parkinson's Disease and Parkinson-like Syndromes, is New[P].FR 2 700 115,1994.
  • 5Kohegyi Imre,Galamb Vilmos.5H-Dibenz[b,f]azepines. Part 4. A Remarkable Substituent Effect in the Hydrogen-transfer Reaction of 10,11-Dihydro-5H-dibenz[b,f]azepine Derivatives[J].Journal of Chemical Research, Synopses,1994, (7):270-271.
  • 6Tecoma Evelyn S.Oxcarbazepine[J].Epilepsia,1999,V40(Suppl. 5), S37-S46.
  • 7Milanese Alberto.Preparation of 10-Oxo-10,11-dihydro-5H-dibenz[b,f]azepin-5-carboxamide[P].WO 9 621 649,1996.
  • 8Schindler Walter,Blattner Hans.5H-Dibenz[b,f]azepine Derivatives[P].US 27 622,1973.
  • 9Morel Charles J,Haflinger Franz.Iminobibenzyl Derivative[P].US 2 762 796,1956.
  • 10Dietrich Henri.Iminobibenzyl Derivatives[P].CH 403 768,1966.

同被引文献23

  • 1谢建伟,苏为科,周兆良.奥卡西平合成路线图解[J].中国医药工业杂志,2005,36(2):123-125. 被引量：5
  • 2刘旭桃,李梅连,肖方青.奥卡西平的合成[J].中国医药工业杂志,2006,37(7):443-445. 被引量：3
  • 3Eidenhammer Gerhard, Altreiter Johann, Schwendinger Karl. Method of producing oxcarbazepine( = 10,11-dihydro-10-oxo-5H- dibenz [ b, f ] azepine-5-carboxamide ) and its intermediate products[P]. WO: 0 055 138,2000.
  • 4Kawashima Kenya, Ishiguro Toshihir. Dibenxoxirenazepine derivatives[ P]. DE :2 246 842,1973.
  • 5Zergenyi Iones. Process for the rearrangement of 10,11-epoxy-10, 11-dihydro-SH-dibenz [ b, f]-azepines to give 10-oxo-10, 11- dihydro-5 H-dibenz [ b ,f] -azepines [ P]. CH :633 271,1982.
  • 6Mannonen Matti Tapani, Hilden Leif. Process for the preparation of 5H-dibenz[ b, f] -azepine [ P]. EP :0 237 952,1987.
  • 7Benes Jan, Soares Da Silva Patricio M V A, Learmonth David Alexander. Derivatives of 10,11-dihydro-10-oxo-SH-dibenz [ b, f] azepine-5-carboxamide[ P]. US : 5 866 566,1999.
  • 8Aufderharr Ernest. Processes for the preparation of an oxo compound,and intermediates required therefore [ P ]. EP: 0 028 028,1981.
  • 9Aufderhaar Ernst, Zergenyi Janoes. Process for preparing 5-cyano- 5H-dibenz [ b, f ] azepine and 5H-dibenz [ b, f ] azepine-5- earboxamide[P]. EP: 0 029 409,1981.
  • 10Schindler Walter, Blatter Hans. New azepine derivatives [ P ]. CH :3 92 515,1965.

引证文献3

二级引证文献2

合成化学
2004年 第6期

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