摘要
目的:探讨慢性阻塞性肺疾病(COPD)稳定期患者血清透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(PCⅢ)与BODE指数(B为体重指数,O为气流阻塞,D为呼吸困难,E为运动能力)的关系。方法:选择60例稳定期COPD患者、20例正常组对比,检测其外周血清HA、LN、PCⅢ含量水平,及其与BODE指数的相关性分析,探讨其在评价COPD患者病情严重程度及预后中的价值。结果:COPD患者血清HA、LN、PCⅢ含量水平均较正常对照组显著升高(P<0.05、P<0.001);中医证型以为血瘀证38.33%、肾阳虚证31.67%为主;相关性分析提示:血清HA、LN、PCⅢ水平,与BODE指数、MMRC、年龄、病史呈正相关(P<0.05、P<0.001),与FEV1%pred、6MWD、BMI则呈负相关(P<0.05、P<0.001)。结论:肾虚血瘀是COPD基本病理机制。血清HA、LN、PCⅢ的水平在一定程度上反映了肺组织的损害及继发肺间质纤维化的病理过程,是反映肺疾病,尤其是肺间质性疾病的一项新指标。
Objective： To investigate the relationship between peripheral serum hyaluronic acid（ HA）, laminin （LN）, precollagen III（PC III）and BODE index in the patients with COPD in stable phase. Methods： 60 cases with COPD in stable phase and 20 healthy cases were chosen to study. HA, LN and PC III were detected and the relationship between BODE and them was analyzed so as to investigate the effect on evaluating the degree of the patient＇s condition and their prognosis. Results： HA, LN and PC III were much higher in treatment group than in control group remarkably （ P 〈 0.05 or P 〈 0. 001 ）. The main TCM Syndromes were syndrome of blood stasis （38.33%） and syndrome of deficiency of kidney-yang（ 31. 67% ）. The dependability analysis suggested that HA, LN and PC III have direct correlation to BODE index, MMRC, age and case history（P 〈0.05 or P 〈0.001 ）, but inverse correlation to FEV1% pred, 6MWD and BMI（P 〈0.05 or P 〈 0. 001 ）. Conclusion： Renal deficiency and blood stasis are the basic pathomechanism in COPD. HA, LN and PC III reflect the impairment of lung tissue and the pathological process to some extent, and can be the new indexes in pulmonary disease especially interstitial lung disease.
出处
《山西中医》
2012年第10期47-50,共4页
Shanxi Journal of Traditional Chinese Medicine
基金
深圳市科技管理局资助项目(编号:20102178)
