摘要
目的 :检测肺癌组织中小鼠双微粒体 (murinedoubleminute 2 ,MDM2 )蛋白的表达。方法 :用Westernblot方法对 3 1例肺癌组织及相应癌旁组织MDM2蛋白表达情况进行测定。结果 :肺癌组织中MDM2蛋白表达量 ( 3 812 3 5± 1115 3 0 )高于癌旁组织 ( 2 90 3 7 0± 14 2 67 4) ,其增高表达率为 77 4%( 2 4/ 3 1) ,差异有统计学意义 ,P =0 0 0 9;肺鳞癌组织中MDM2蛋白表达增高率为77 3 % ( 17/ 2 2 ) ,肺腺癌组织中为 7/ 7;1例小细胞肺癌和 1例大细胞肺癌组织中MDM2蛋白表达均降低。结论 :MDM2在肺癌的发生过程中有一定作用。
OBJECTIVE:To detect the expression of MDM2(murine double minute 2) in lung cancer tissues and cancer-related tissues.METHODS:Western blot was used to detect the expression of MDM2 in 31 lung cancer tissues and peri-cancer tissues.RESULTS: The expression of MDM2 protein (38 123.5±11 153.0) in lung cancer tissues was significantly higher than that in peri-cancer tissues (29 037.0±14 267.4), the higher rate was 77.4%(24/31).Seventeen cases (77.3%) had the overexpression of MDM2 protein in 22 lung squamous cancer tissues, all the 7 tissues of lung adenocarcinoma had the overexpression of MDM2 protein,but 1 tissue with small cell lung cancer and 1 tissue of the big-cell lung cancer had the low expression of MDM2 protein.CONCLUSION: MDM2 plays an important role in the oncogenesis of lung cancer.
出处
《肿瘤防治杂志》
CAS
2004年第11期1154-1155,共2页
China Journal of Cancer Prevention and Treatment
