摘要
目的 探讨MDM 2基因蛋白与p2 1、p5 3蛋白在胃癌、食管癌中表达的相关性。 方法 对 41例胃癌、45例食管癌标本 ,进行石蜡切片和S P免疫组织化学染色。结果 MDM 2、p2 1和 p5 3在胃癌、食管癌中的表达率分别为 6 7.44% (5 8/86 )、6 1.6 3 % (5 3/86 )和 30 .2 3 % (2 6 /86 )。MDM 2与 p2 1蛋白表达呈正相关 ,与p5 3蛋白表达呈负相关 (rs=-0 .4932 )。结论 MDM 2和 p5 3蛋白在消化道癌瘤的发生、发展过程中具有互相排斥和调节作用 ,而MDM 2和 p2
Objective To explore the interrelation between MDM2 and p21、p53 protein expression in gastric and esophageal cancer.Methods Samples from 45 cases of esophageal cancer and 41 cases of gastric carcinoma were studied by immunohistochemical dye.Results The total positive rate of MDM2、p21and p53 protein was 67.44%(58/86),61.63(53/86) and 30.23%(26/86) respectively.Immunoactivity of MDM2 was positively correlated with p21 protein,and reversedly with p53 protein(r s=-0.4932).Conclusion The interrelation between MDM2 and p53 protein is mutually exclusive and regulation in carcinogenesis,and development of gastrointestinal cancer.The interaction between MDM2 and p21 protein mutually is not evident.
出处
《实用癌症杂志》
2001年第1期34-35,59,共3页
The Practical Journal of Cancer
基金
河北省卫生厅资助项目(No.94002)
关键词
免疫组织化学
胃癌
食管癌
基因蛋白
Immunohistochemistry
Gastric cancer
Esophageal cancer
Gene protein
