摘要
目的 :观察磷酸奥司他韦治疗早期流感的疗效。方法 :10 0例符合早期流感标准的病例 ,随机分成两组 ,A组 5 0例 ,磷酸奥司他韦 75mg ,每日 2次口服 ,疗程 2～ 5d ;B组 5 0例 ,常规对症治疗 (新康泰克 ) ,疗程 5～ 7d。结果 :奥司他韦治疗组在第2 4h和第 72h症状缓解率分别为 38%和 6 8% ,明显高于对照组相应的 18%和 4 4 % (P <0 .0 1)。且奥司他韦治疗减少了并发症发生率、抗生素应用量和家庭二代感染率 ,耐受性良好 ,未见严重不良反应。结论 :磷酸奥司他韦作为抗流感病毒药物治疗国人早期临床流感较安全有效。
Objective: To evaluate the efficacy of oseltamivir in the treatment of early influenza. Methods: 100 patients with early clinic influenza were randomizedly divided into two groups. Control group received route symptom-relieve treatment includ oral kangtaike etc. Oseltamivir group received route treatment plus oral oseltamivir 75mg twice daily for 2-5 days. Results: The symptom-relieve rates at the 24,72 hour in oseltamivir group(38% and 68%) were significantly higher than that of controls(18% and 44%,P<0.01 respectively). Compared with controls, oseltamivir treatment reduced further spread of influenza within household (4/121 vs 14/133,P<0.01)and influenza complication (5 vs 12,P<0.05). Oseltamivir treatment was well tolerated in all patients, No drug-related serious adverse events were reported in both groups. Conclusion:Oseltamivir is safe and effevtive as an antiinfluenza drug for treating early clinic influenza.
出处
《中国临床医学》
2004年第5期868-869,共2页
Chinese Journal of Clinical Medicine
