摘要
目的分析甲型H1N1流感患者病毒核糖核酸(RNA)阴转的规律和特点。方法对北京地坛医院收治的38例甲型H1N1流感确诊患者的RNA转归情况、可能影响RNA转归的相关因素进行统计分析。结果甲型H1N1流感患者病毒RNA一般在病程的第6天发生阴转,热程越长、流感样症状持续时间越长,RNA阴转的时间越长。早期应用磷酸奥司他韦抗病毒治疗可促进RNA阴转、缩短热程和促使症状恢复,但性别、年龄不影响RNA的阴转。结论体温和抗病毒治疗是影响甲型H1N1流感患者病毒RNA阴转的主要因素,热程、流感样症状持续时间也有一定影响,但仍有必要继续观察和探索。
Objective To investigate the rules and characteristics of negative conversion of ribonucleic acid （RNA） in the patients with influenza A （H1N1）. Methods Negative conversion of RNA and the relative factors affecting negative conversion of RNA were analyzed statistically in 38 patients with influenza A （H1N1） treated in Beijing Ditan Hospital. Results Influenza A （HINI） virus RNA achieved negative conversion at day 6 of illness duration. The longer the duration of fever and influenza-like symptoms, the longer the time for negative conversion of RNA. Early antiviral treatment using oseltamivir could promote negative conversion of RNA, reduce the duration of fever and promote recovery, but gender and age did not affect negative conversion of RNA. Conclusions Body temperature and antiviral therapy are the major factors affecting negative conversion of RNA in the patients with influenza A （H1N1）. The duration of fever and influenza-like symptoms also affect negative conversion of RNA. However, it is necessary for further observation and investigation.
出处
《传染病信息》
2010年第4期227-229,共3页
Infectious Disease Information
基金
国家科技部支撑计划课题--甲型H1N1流感联防联控应急科研项目<临床救治方案评价与病例资源集成研究>
关键词
流感病毒A型
H1N1亚型
核酸类
抗病毒药
体温
influenza A virus, H1N1 subtype
nucleic acids
antiviral agents
body temperature
