摘要
采用离子趋向凝胶化法制备了胰岛素壳聚糖胶态微粒,并考察了外观、粒径和体外释药性能。所得产品呈球形,表面光滑圆整,平均粒径为276nm,多分散系数为0.08。体外释药呈pH依赖性,释药速度受载药量及泊洛沙姆188含量的影响。
Insulin-loaded chitosan colloidal nanoparticles were prepared using ionotropic gelation technique. Theshape, size and in vitro release of the prepared nanoparticles were examined. The results showed that the nanoparticles werespherical and smooth with a mean particle size of 276nm and a polydisperse coefficient of 0.08. The in vitro release ofinsulin from the colloidal nanoparticles was pH-dependent, the drug loading and the poloxamer188 content had an influenceon the release speed.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第11期655-657,共3页
Chinese Journal of Pharmaceuticals
关键词
胰岛素
壳聚糖
胶态纳米粒
体外释药
insulin
chitosan
colloidal nanoparticles
in vitro release
