摘要
血管生成素(angiopoietin,Ang)是特异性作用于血管内皮细胞的生长因子,主要由Ang-1和Ang-2组成;Tie2(tyrosinekinasethatcontainsim-munoglubin-likeloopsandepidermalgrowthfac-tor-similardomains2)是其共同受体。Ang-1促使血管成熟,维持血管稳定。Ang-2则拮抗Ang-1的作用,始动病理性新生血管形成。在眼部新生血管形成过程中Ang/Tie2受体途径起重要作用,抑制Ang/Tie2受体途径可以抑制眼部新生血管形成。
Angiopoietins family is one that specifically acts on vascular endothelial. This family mainly includes Ang-1 and Ang-2. Tie2(tyrosine kinase that contains immunoglubin-like loops and epidermal growth factor-similar domains 2)is their receptors. Ang-1 plays an important role in promoting maturity and maintaining stabilization of vascular. Ang-2 is the natural antagonist of Ang-1, and initializes pathological neovascularization. Ang/Tie2 pathway plays an important role during the formation of pathological neovascularization in eyes. Blockade of this pathway may effectively inhibit the formation of pathological neovascularization in eyes.·
出处
《国际眼科杂志》
CAS
2004年第5期887-890,共4页
International Eye Science
