摘要
目的探讨ｃｙｃｌｉＤ１、ＰＣＮＡ表达在卵巢癌发病中的作用及其与预后的关系。方法应用ＳＡＢＣ免疫组化技术，检测４０例卵巢上皮性癌、１２例良性卵巢上皮性肿瘤和１０例正常卵巢中ｃｙｃｌｉｎＤ１、ＰＣＮＡ的表达，并对两者表达在卵巢上皮性癌临床分期、组织学分级、组织学类型和生存时间之关系进行探讨。结果（１）ｃｙｃｌｉｎＤ１阳性表达多见于临床期别晚和生存期短的病例组（Ｐ＜０．０５），低分化者阳性表达高于高分化者，Ⅲ级与Ⅱ级、Ⅰ级比较，差异有显著性（Ｐ＜０．０５）。（２）ＰＣＮＡ指数在临床期别晚、低分化和生存期短的病例组明显高于临床期别早、高分化和生存期长的病例组（Ｐ＜０．０１，Ｐ＜０．０１和Ｐ＜０．０１）。（３）ｃｙｃｌｉｎＤ１表达与ＰＣＮＡ指数呈正相关。结论ｃｙｃｌｉｎＤ１、ＰＣＮＡ表达与卵巢上皮性癌的临床病理指标有关，对估计其进展、判断预后具有重要意义。
Objective To explore the potential role of cyclinD1 .PCNA expression in the progression of ovarian carcinoma and to study their relationship with prognosis. Methods Using immunohistochemical staining technique,the expression of cyclinD, .PCNA were examined in 40 cases of ovarian epithelial carcinoma, 12 cases of benign ovarian epithelial tumors and 10 cases of normal ovaries. The relationship between the expression of cyclinD1、 PCNA and the clinical stage, differentiated grade, histological type and survival time were analyzed. Results (l )The expression of cyclinD1 .PCNA in the later clinical stage and shorter survival time were higher than those in the earlier clinical stage and longer survival time (P<0. 05);It was higher in poorly differentiated tumors than that in well differentiated tumors. There was an apparent difference while grade Ⅲ was compared with grade Ⅱ or grade Ⅰ (P<0. 05); (2)The PCNA expression correlated with the clinical stage,differentiation grade and survival time. The PCNA index in later clinical stage,poor differentiation grade and shorter surivial time were higher than those in the earlier clinical stage, well differentiation grade and longer survival time (PRO. 01, P<0.01 and P<0. 01 ); (3)There was positive correlation between the expression of cyclinD1 and PCNA index. Conclusion The expression of cyclinD1 .PCNA was closely correlated with the clinicopathological parameters of ovarian carcinoma. Detection of cyclinD1 PCNA is of value in progression and clinical outcome of ovarian epithelial carcinoma.
出处
《实用肿瘤杂志》
CAS
北大核心
2000年第6期388-390,共3页
Journal of Practical Oncology
