摘要
目的 :探讨p16蛋白和PCNA与胃癌发生、发展的关系。方法 :应用免疫组化LSAB法对 10 4例胃癌进行了p16蛋白和PCNA的检测。结果 :正常胃粘膜、不典型增生及胃癌均有程度不同的p16蛋白的表达 ,分别为 81.82 % ,4 5.4 6%及 50 .0 0 %。PCNA指数与肿瘤分化程度及临床分期有关。p16蛋白阳性者的PCNA指数低于p16蛋白阴性者 (P <0 .0 5)。结论 :p16蛋白和PCNA与胃癌的发生、发展有关 。
Objective To evaluate the significance of p16 protein and PCNA in pathogenisis and development of gastric carcinoma.Methods The p16 protein and PCNA were detected by immunohistochemistry in 104 surgically resected specimens including gastric carcinoma.Results The positive rate of p16 immunoreactivity was 81.82 %,45.46% and 50% respectively in normal gastric mucosa,atypical hyperplasia and gastric carcinoma.The PCNA labeling index (PCNA LI) was related to the histological grades and clinical grades of the disease .The PCNA might play some roles in the carcinoma.Conclusions p16 oncogene protein and PCNA might play some roles in the carcinogenesis of human gastric carcinoma,might be an important marker for reflecting the biological behavior and prognosis of gastric carcinoma.
出处
《肿瘤防治杂志》
2001年第1期28-29,共2页
China Journal of Cancer Prevention and Treatment
关键词
P16蛋白
抗原
增殖细胞核
免疫组织化学
胃癌
stomach neoplasms
p16 protein
proliferating cell nuclear antigen
immunohistochemistry
