摘要
目的 :探讨硒对新生儿神经行为发育和甲状腺功能调节的作用。方法 :采用 Ebselen对围产期铅暴露进行干预流调 ,测定脐血铅、血硒及促甲状腺素、活性甲状腺素 ,在新生儿出生后 d2 6～ 2 8采用双盲法进行神经行为发育 (NBNA)评价。结果 :干预组脐血铅均值为 0 .34μmol/L,显著低于对照组的 0 .5 μmol/L,血硒、血锌、GSH- Px均高于对照组 (P<0 .0 1) ,TT3、、TT3/TT4 比值、FT3/FT4 比值均高于对照组。结论 :采用硒干预对降低新生儿铅毒 ,改善微量营养素 ,提升抗氧化功能 ,改善甲状腺功能代谢 ,保护新生儿智力正常发育有明显促进作用。
Objective:To explore the effect of selenium on the development of newborn's nervous behavior and throxine.Methods:The intervention epide miological investigation was proceeded with the perinatal lead exposure by using Ebselen,and the umbilical blood lead was detected by atomic absorptionmethod and the umbilical blood selenium was detected by double ways fluoreson day 26～28 of newborn was evaluated by using double blind method.Results:The navel blood lead of intervention group was 0.34μmol/L,which was lower than the control group remarkably(0.5μmol/L),the blood selenium,zinc and GSH-Px were all higher than the control( P <0.01),the content of LPO was lower than the control( P< 0.01).The percent of NBNA> in intervention group was 65.8%,which is obviously better than the control( P <0.01) T_3/T_3 value of intervention group was higher than the coutrol group.Conclusion:The perinatal lead intervention has obviously promotion on alleviating the lead toxin of newborn,improving the level of trace nutrients,enhancing the ability of antioxidation,improving the metabolize of throxine and protecting the normal development of neworn's intelligence.
出处
《现代预防医学》
CAS
2004年第4期513-514,共2页
Modern Preventive Medicine
关键词
硒
新生儿
神经行为发育
甲状腺功能
铅暴露
Lead
Selenium
GSH-Px
Umbilical blood
Development of nervous behavior
Throxine
Intervention
