摘要
【目的】探讨生长激素对原发性肝癌的作用及联合化疗的治疗效果。【方法】建立人原发性肝癌原位移植瘤模型,并将23只荷瘤裸小鼠随机分成对照组(A组),化疗药物治疗组(B组),生长激素组(C组),生长激素联合化疗药物治疗组(D组);治疗2周,观察各组裸小鼠的治疗效果。【结果】与实验前比较,生长激素组裸小鼠体质量增加,差异具统计学意义(P<0.01);实验后,裸小鼠肿瘤组织的平均质量、体积在化疗药物治疗组明显低于对照组(P<0.01),在生长激素组明显高于其他组,差异有统计学意义(P<0.01);而在生长激素联合化疗药物治疗组与对照组的比较,差异无统计学意义(P>0.05)。【结论】生长激素可能是通过直接促进肿瘤细胞DNA合成来刺激实体性肿瘤的生长,生长激素联合有效化疗药物治疗肿瘤的方式可以降低生长激素对肿瘤的潜在危险性。
To investigate the effect of recombined human growth hormone(rhGH) on the hepatocellular carcinoma implanted in nude mice and its efficacy in combining with chemotherapy. Human hepatocellular carcinoma model was established in nude mice. And 23 nude mice were divided into 4 groups: control group ( Group A), chemotherapy group (Group B ), rhGH group (Group C ),and chemotherapy combined with rhGH group(Group D). The results of each group were observed in two weeks.Body mass was significantly increased after rhGH therapy (P< 0.01). After the treatment, the average tumor mass and volume were significantly reduced in chemotherapy group compared with control group(P < 0.01);but they were significantly increased in rhGH group compared with the other groups(P < 0.01). It was no significant difference between the chemotherapy combined with rhGH group and the control group(P >0.05).[Conclusion ]rhGH may stimulate growth of the solid tumor by directly promoting synthesis of tumor cell DNA. Using the rhGH combined with chemotherapy may reduce the potential danger of rhGH on growth of tumor.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2004年第4期315-318,共4页
Journal of Sun Yat-Sen University:Medical Sciences
基金
广东省医学科学研究基金资助项目(B2001020)
