摘要
目的 :探讨恩丹西酮与胃复安联用预防化疗呕吐的疗效。方法 :采用自身对照的方法 ,观察 1 1 2例恶性肿瘤患者以顺铂 (4 0 mg/ d× 3d)为主的联合化疗 ,于第 1、2周期分别用恩丹西酮、恩丹西酮与胃复安联合应用 ,预防化疗恶心呕吐反应。结果 :有效率分别为 86 .6 1 %、97.32 % ,二者有显著性差异 (P<0 .0 5 ) ,且恩丹西酮与胃复安联合使恩丹西酮用量减少 1 / 2 ,未出现锥体外系反应患者 ,其便秘、腹胀发生率较低 ,二者比较有差异性 (P<0 .0 5 )。结论 :恩丹西酮与胃复安联用预防化疗引起的恶心。
Objective:To explore the efficacy of ondansetron and metoclopramide in preventing the vomiting caused by chemotherapy.Methods:112 cases of cancer who were treated mainly by the combination of cisplatin were studied.The dosage of cisplatin was 40mg per day.The treatment course was three days.The cases in control group were given only ondansetron in the first treatment course.The cases in experimental group were given both ondansetron and metoclopramide in the second treatment course.The results were recorded and compared.Results:The efficacy rate in control and experimental groups were 86.61% and 97.32%,respectively.The significant difference between the two groups was found ( P <0.05).The dosage of ondansetron could be reduced to 50% when combinning with metoclopradmide.No extrapyramidal reaction was found.The constipation rate was also low in experimental group ( P <0.05).Conclusion:The combination of ondansetron and metoclopramide has the advantage in preventing the vomiting caused by chemotherapy.
出处
《华夏医学》
2004年第4期498-500,共3页
Acta Medicinae Sinica
关键词
恩丹西酮
胃复安
化疗反应
ondansetron
metoclopramide
chemotherapy reaction
