摘要
盐酸格雷西龙是南京军事研究所研制的第四类新药。本文采用随机分组、自身对照、交叉设计的方法，对37例恶性肿瘤化疗病人进行预防呕吐的临床观察，比较盐酸格雷西龙与进口康泉及国产灭吐灵止吐疗效反应。联合化疗方案为含有顺铂（80mg／m2）或阿霉素（40mg／m2），盐酸格雷西龙或康泉3mg加生理盐水30～50ml稀释，化疗前5分钟静脉推注，第1、3天；灭吐灵20mg，化疗当日肌注，每日2次。每一病人用同一方案化疗2周期。结果表明盐酸格雷西龙注射液的止吐有效率（86．5％）与康泉止吐率（80％）相似，明显好于灭吐灵对照组（有效率41．2％）。其毒副作用与康泉相似，主要为头痛头晕、便秘及腹部不适。头痛头晕发生率为5．4％，便秘及腹部不适为8．1％，无灭吐灵的锥体外系反应。作者认为盐酸格雷西龙是一个安全、有效、经济的预防化疗引起的消化道反应的国产止吐药物。
Domestic Granisetron is the fourth - classified new ding produced by Nanjing Military Medical Institute. In this study, 37 patients with malignant tumor were treated with granisetron(domestic), kytril andmetodopramidle separatidy to compare the effects of the drugs on the prevention therapy of vomitinginduced by cancer chemotherapy. The combination regimen included cisplatin (80mg/m2) or adriangcin(40mg/m2),3mg domeotic granisetron or 3mg kytril diluted with 30 ~ 50ml of nounal saline for intravenous injection for 5 minutes on day 1 and day 3 .20 mg metoclopramide was given intramuscularly twicea day conecurrently with chemotherapy.Two cycles were given for each patients. The response at of domestic granisetron on antienctic effects was 86. 5% which is similar to 80% of kytril. It was much higherthan 41 .2% of metoclopromide. As well as that of kiwi, toticities included 5. 4% headache and dizziness and 8. 1 % constipation and abdominal malaise. Domestis granisetron is a safe and effective antiemticagent in the premunition therapy of gastrointestinal toxicities induced by chemotherapy of cancer.
出处
《河南肿瘤学杂志》
1998年第1期24-26,共3页
Henan Journal of Oncology
