摘要
目的:探讨肥大细胞(MC)和血管内皮细胞在银屑病发病中的作用。方法:采用组织化学和免疫组化的方法,观察寻常性银屑病皮损处MC和CD34标记血管内皮细胞的分布情况。结果:经甲苯胺蓝特殊染色发现,银屑病患者真皮区的MC密度在进行期(33.07±14.63)个/mm2,高于静止期(21.80±4.86)个/mm2,静止期又高于正常对照组(15.85±6.93)个/mm2,它们之间的差异均有显著性;免疫组化观察发现,银屑病真皮区CD34标记的微血管密度在进行期(29.31±4.04)个/mm2,明显高于静止期(22.31±2.07)个/mm2,而静止期又明显高于正常对照组(18.81±2.59)个/mm2。结论:寻常性银屑病皮损处真皮内肥大细胞和血管内皮细胞密度明显增加,且与病情变化有关。
Objective:To study the roles of mast cells and vascular endothelial cells in psoriatic lesions.Methods:The distributions of mast cells and CD34positive vascular endothelial cells were observed by using histochemical and immuno-histochemical methods.Results:A significantly higher density of mast cells and CD34positive vascular endothelial cells in the superficial dermis of the progressive psoriatic lesions was observed compared with that in the static psoriatic lesions.Conclusions:The density of mast cells and vascular endothelial cells in the superficial dermis of the psoriatic lesions is higher than that in the normal control,and is correlated with the severity of the disease.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2004年第8期468-470,共3页
Journal of Clinical Dermatology
