摘要
目的 探讨半胱氨酸天冬氨酸蛋白酶 3(Caspase 3)的表达及其与血管瘤消退的关系。 方法 采用免疫组化SP法检测Caspase 3在 79例血管瘤和 5例正常皮肤组织中的表达。 结果 79例血管瘤患者血管组织的Caspase 3阳性表达率在增殖期、消退期、退化期分别为 5 2 .4 %、91.2 %和 83.3% ,退化期、消退期的阳性表达高于增殖期 (P<0 .0 5 ,P<0 .0 1) ,也明显高于正常对照组 (P<0 .0 1) ,而增殖期与正常对照组阳性表达的差异无统计学意义 (P>0 .0 5 )。结论 Caspase 3参与了血管瘤由增殖期转变为消退期的病理发生过程 ,Caspase 3的活化诱导了细胞凋亡的发生 。
Objective To study the relationship between expression of Caspase 3 and regression of hemangioma. Methods Caspase 3 expression was detected in 79 hemangiomas and 5 normal skin tissues by immunohistochemistry (SP). Results In 79 hemangiomas, the positive rates of Caspase 3 expression in proliferating, involuting and involuted phases were 52.4%, 91.2% and 83.3%, respectively. The expression of Caspase 3 in involuted and involuting phases was higher than proliferating phase( P <0.05, P <0.01) and control group( P <0.01). There was no statistical difference between the latter two groups ( P >0.05). Conclusion Caspase 3 is involved in the converting of hemangiomas from proliferating phase into involuting phase. The activation of Caspase 3 may induce apoptosis of endothelial cells, thus leading to the regression of hemagioma.
出处
《中国普外基础与临床杂志》
CAS
2004年第4期311-313,共3页
Chinese Journal of Bases and Clinics In General Surgery
