摘要
目的探讨ER、CerbB-2、Caspase-3在乳腺浸润性导管癌组织中的表达情况及与临床病理参数的关系。方法应用免疫组化SP法检测132例乳腺浸润性导管癌中ER、CerbB-2、Caspase-3的表达情况。结果 ER、CerbB-2、Caspase-3在癌组织中的表达分别为56.1%(74/132)、36.4%(48/132)、59.8%(79/132)。其中ER表达阳性及阴性癌组织中淋巴结转移率分别为14.9%(11/74)、37.9%(22/58);ER表达阳性及阴性癌组织中组织学分级1、2级比例分别为83.8%(62/74)、56.9%(33/58);CerbB-2表达阳性及阴性癌组织中淋巴结转移率分别为37.5%(18/48)、17.9%(15/84);CerbB-2表达阳性及阴性癌组织中组织学分级1、2级比例分别为77.1%(37/48)、69.0%(58/84);Caspase-3表达阳性及阴性癌组织中淋巴结转移率分别为15.2%(12/79)、39.6%(21/53);Caspase-3表达阳性及阴性癌组织中组织学分级1、2级比例分别为83.5%(66/79)、54.7%(29/53)。除去不同CerbB-2表达癌组织中组织学分级1、2外,以上参数均有显著差异。结论乳腺癌的发生发展受到多种因子的调控,细胞凋亡受到抑制是重要因素之一。
Objective To discuss the expression of ER,CerbB-2,Caspase-3in breast cancer and the relationship of clinical pathological parameters.Methods Using immunity histochemistry SP examines the expression of ER,CerbB-2,Caspase-3in132 cases of breast cancer.Results The expression of ER,CerbB-2,Caspase-3 was 56.1%（74/132）,36.4%（48/132）and 59.8%（79/132）.The lymph node metastasis rate in breast cancer that ER express positive and negative was 14.9%（11/74）,37.9%（22/58）;the histological grading 1,2in breast cancer that ER express positive and negative was 83.8%（62/74）,56.9%（33/58）.The lymph node metastasis rate in breast cancer that CerbB-2 express positive and negative was 37.5%（18/48）,17.9%（15/84）;The histological grading 1、2 in breast cancer that CerbB-2 express positive and negative was 77.1%（37/48）、69%（58/84）.The lymph node metastasis rate in breast cancer that Caspase-3 express positive and negative was 15.2%（12/79）、39.6%（21/53）;The histological grading 1and 2 in breast cancer that Caspase-3 express positive and negative was 83.5%（66/79）and 54.7%（29/53）.There was significant difference between these groups except histological grading 1,2in breast cancer that different CerbB-2 expression.Conclusion The occurrence and development of breast cancer is regulated by many factors,and the inhibition of apoptosis is one of the important factors.
出处
《中国煤炭工业医学杂志》
2017年第2期145-148,共4页
Chinese Journal of Coal Industry Medicine
基金
2008年唐山市科学研究与指导计划项目(编号:08130231c)
