摘要
罗红霉素为半合成的大环内酯类抗生素。合成路线基本上都是以硫氰酸、红霉素为原料 ,经肟化成红霉素肟 ,再和甲氧乙氧氯甲醚反应得罗红霉素。参考国内外的文献 ,对罗红霉素工艺路线进行了改进。在红霉素肟的制备过程中改用无水乙醇作溶剂 ,并用乙酸乙酯提取 ,减压蒸馏后再精制的方法 ,得到罗红霉素。实验部分包括红霉素肟的制备和罗红霉素的制备。
Roxithromycin is a kind of semi-synthetical antibiotic drugs of large ring lactone. Roxithromycin is produced basically by synthesize from β-methoxy ethoxy methyl chloride and Oximido erythrocin that has been oximated from Sulfocyanic acid and Erythromycin. the technical course of Roxithromycin preparation referred to the literature at home and abroad was ameliorated.
出处
《辽宁化工》
CAS
2004年第6期325-325,338,共2页
Liaoning Chemical Industry
关键词
罗红霉素
合成
抗生素
Roxithromycin
Synthesis
Antibiotic
