摘要
本研究探讨了血卟啉单甲醚(PsD-044)对狗眼球的急性和亚急性光毒作用引起的病理改变,发现PsD-044可致角巩膜炎和巩膜血管周围炎。光毒性睫状体炎和视网膜炎性水肿以延期处死的动物眼球为重。提示服用PsD-044后,眼球避光保护是必须的。
The histopathological changs of the dog eyes caused by acute and subacute toxic effectsof hematoporphyrin monoether--PsD-044 were observed in this research. The results showed thatPsD-044 could lead to keratoscleritis and scleral perivasculitis. Phototoxic cyclitis and inflammatory edema of the retina were more serious in deferred killed animals, suggesting that it is necessary to avoid exposure to light after the administration of PsD-044.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1993年第3期246-248,共3页
Academic Journal of Second Military Medical University
关键词
血卟啉单甲醚
光毒性
视网膜
hematoporphrin derivative
hematoporphyrin monoether
phototoxicity
ciliary body
retina
optic nerve
animal
dogs
