摘要
器官纤维化可发生于不同的组织器官,其发病率高、危害性大,尚缺乏有效的治疗药物。近年发现的新型抗纤维化小分子化合物——氟非尼酮,为纤维化疾病的治疗带来了希望。氟非尼酮可以通过抗炎症反应、抗氧化应激、抗细胞凋亡、抑制肌成纤维细胞的活化与增殖、促进细胞外基质降解及调节信号转导等多种途径,起到抗器官纤维化的作用,明显减轻肾、肝及肺的纤维化程度。
Fibrosis can occur in diff erent organs with high incidence rate and great danger. It still lacks eff ective drugs for prevention of fibrosis. Fluorofenidone is a newly developed drug with anti-fibrotic activity, which provides a new hope for treating the progressive fibrotic diseases. Recent studies have shown that fluorofenidone is a multifunctional small molecule with anti-inflammatory, antioxidative and anti-apoptotic eff ects. It can inhibit the activation and proliferation of myofibroblasts, promote the degradation of extracellular matrix and regulate the cellular signal transmission. Fluorofenidone can be applied to att enuate the progression of renal, hepatic and pulmonary fibrosis.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2015年第2期208-213,共6页
Journal of Central South University ：Medical Science
基金
国家自然科学基金(81273575)~~
关键词
器官纤维化
氟非尼酮
抗纤维化
肾
肝
肺
organ fibrosis
fluorofenidone
anti-fibrosis
kidney
liver
lung
