摘要
本研究旨在随机比较负压吸宫术前3h一次口服米索前列醇400μg或阴道给药对于早孕妇女宫颈扩张的临床效果。共征集对象150例,组Ⅰ(口服)、组Ⅱ(阴道给药)和组Ⅲ(对照组)各50例。结果显示组Ⅰ、Ⅱ对象中Hegar氏扩张器无阻力通过宫颈内口最大直径分别为6.15±0.35mm((?)±s,下同)和6.12±0.37mm,明显大于对照组(4.85±0.35mm,P<0.001),而术中出血组Ⅰ和组Ⅱ则分别为14.92±5.39ml和13.61±4.29ml,与对照组(20.53±5.17ml)相比亦有显著差异(P<0.001)。且用药组术中恶心与腹痛的发生率明显低于对照组(P<0.001)。本研究提示米索前列醇无论口服或阴道给药,对于早孕妇女子宫颈均有明显扩张与软化作用,且可明显减少负压吸宫术中出血量。
The purpose of this study is to compare the efficacy of 400μg misoprostol in single dose taken orally and vaginally for cervical dilatation in early pregnancy women. One hundred and fifty subjects were recruited and allocated into Group Ⅰ (orally), Group Ⅱ (vaginally) or Group Ⅲ (control) in random. The results showed that maximal diameters of Hegars dilator passing through the cervix resistlessly were 6. 15 ± 0. 35mm (X ± S), so were the following values and 6. 12± 0. 37mm respectively in Group Ⅰ andⅡ, and significantly larger than that in Group Ⅲ (4.85±0.35mm,P<0.001). While volumes of blood loss in vacuum aspiration were 14. 92± 5.39ml and 13.61 ± 4.29ml respectively in Group Ⅰ and Ⅱ , significantly less than that in Group Ⅲ (20.53± 5.17mm, P < 0. 001). In addition, there were lower incidences of nausea and pelvic pain in both treatment groups as compared with control group during operation (P<0.001).The study indicated that misoprostol given orally and vagially prior to vacuum aspiration was effective for cervical dilatation in pregnant women and for reduction in bleeding amount during operation.
出处
《中国计划生育学杂志》
1998年第2期75-76,共2页
Chinese Journal of Family Planning
关键词
宫颈扩张
米索前列醇
人工流产
Cervical dilatation Misoprostol Induced abortion
