摘要
目的:探讨早期干预对首发精神分裂症患者生活质量的影响。方法:将97例首发精神分裂症患者随机分为研究组(n=49)和对照组(n=48),研究组从治疗后开始即接受药物、心理、社会的综合干预措施,对照组仅使用单一药物治疗。于治疗前、出院1年后采用阳性和阴性症状量表(PANSS)及生活质量量表(WHOQOL-100)进行精神症状和生活质量的评定。结果:出院1年后,研究组PANSS阴性量表分改善明显优于对照组(9.04±1.80和13.20±1.90),差异有显著性意义(t=11.24,P<0.01);对生活质量的影响除精神支柱外均明显提高,与治疗前比较差异有显著性意义(t=3.85～26.41,P均<0.01);对照组患者的生理领域、独立性领域、精神支柱没有明显改善(t=7.70,6.45,0.64,P均>0.05)。结论:早期干预有助于提高首发精神分裂症状患者的生活质量。
AIM:To investigate the influence of early intervention on the quality of life (QOL) in first episode schizophrenic patients. METHODS:Totally 97 patients with first episode schizophrenia were randomly divided into study group(n=49) and control group(n=48).Patients in the study group received drug treatment and psychological and social interventions,while patients in the control group received drug treatment only. All the patients were evaluated with the positive and negative symptoms scale (PANSS) and WHO Quality of Life Survey(WHOQOL 100) before treatment and 1 year after discharge. RESULTS:One year after discharge,the negative rating scale of PANSS in the study group was improved obviously better than that in the control group (9.04±1.80 vs 13.20±1.90),with significant difference(t=11.24,P< 0.01),and QOL was remarkably enhanced except mental support,significantly different from before treatment(t=3.85-26.41,P< 0.01).In the control group,physiological field,independent field and mental support were not greatly improved(t=7.70,6.45,0.64,P >0.05). CONCLUSION:Early intervention is good for the improvement of the QOL in first episode schizophrenic patients.
出处
《中国临床康复》
CSCD
2004年第18期3464-3465,共2页
Chinese Journal of Clinical Rehabilitation
