摘要
目的探讨奎硫平、奋乃静对精神分裂症患者生活质量的影响。方法符合CCMD-3诊断标准的精神分裂症患者分为奎硫平组（30例）与奋乃静组（为对照组30例）进行了3个月的临床研究，用PANSS、WHO．QOL-100分别评定患者的精神症状和生活质量。结果3个月治疗后奎硫平组患者PANSS总分和阴性因子分改善优于奋乃静组；奎硫平对患者生活质量的影响除精神支柱外均有明显提高；奋乃静仅能部分提高患者的生活质量，但对患者的生活、心理和独立性领域没有明显改善。结论奎硫平对精神分裂症患者的生活质量的改善优于奋乃静。
Objective To study the respeltine effects of quetiapine and perphenazine upon thelife quality of patients with schizophrenia. Methods Two groups of patients eonforrning to the CCMD -3 diagnosis standa rd,with each consisting of 30 persons ,werw treaeated and studied respectively with quetiapineand perphenazine for a period of three months. Afterwards ,the mental state and life quality of the two groups were separately evaluated with PANSS and WHO. QOL - 100. Results Through three months of treatment, the group taking quetiapine acquired bigger improvements in terms of total PANSS score and negative factor scores. Perphenazine group had move adverse reactions than quetiapine group. For the quetipine group, all the aspehs of life quality, except for spiritual pillar, were remarkably enhanced, while for the perphenazine group,but for partial life quality improvement, there were no notable achievements in the fields of physiology, psychology and independence. Conclusion Quetiapine is superion to perphenazine on the quality of life first - opisode sehizophreniee.
