摘要
目的 制备淋巴结靶向性抗癌纳米微粒———平阳霉素—活性炭纳米微粒 ,用于治疗口腔癌颈淋巴结转移灶。方法 制备活性炭纳米微粒 (CH_NP) ,选择对口腔癌高度敏感的平阳霉素 (PYM)为模型药物 ,考察活性炭纳米微粒对平阳霉素吸附效率。结果 活性炭纳米微粒的粒径分布为 136～ 5 4 0nm ,平均粒径为 178nm ,活性炭纳米微粒投入比例的增高 ,对平阳霉素的吸附率相应增高 ,10∶1质量比下可达到 99 38%的吸附。结论 活性炭纳米微粒对平阳霉素的吸附率高 ,制备PYM_CH_NP行口腔癌周局部注射可使靶向淋巴结转移灶获得有效治疗效果。
Objective To prepare anticancer nanoparticles for targeting therapy for oral cancer lymph node metastasis.Methods The activated carbon nanoparticles(CH-NP) were prepared for drug carrier. Pingyangmycin(PYM), a high sensitive anti-cancer drug for oral squamous cell carcinoma, were selected as model drug. The activated carbon nanoparticles and PYM were mixed with saline and shaken 20 minutes so that PYM was absorbed on activated carbon enough, resulting in a new formulation of PYM (PYM-CH-NP). The absorbency of PYM on activated carbon nanoparticles was evaluated.Results The diameter distribution for CH-NP ranged form 136 nm to 540 nm, the average diameter was 176 nm.The proportion of CH-NP to PYM was increased and more absorbency of PYM on activated carbon nanoparticles was achieved.Conclusion The activated carbon nanoparticles has high absorbency of PYM. The new formulation PYM-CH-NP can be used as targeting therapy of cervical lymph node metastasis by peri-cancer submucosal injection.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2004年第3期183-185,共3页
West China Journal of Stomatology
基金
卫生部科学基金资助项目 (98_1_2 2 1 )
关键词
平阳霉素
活性炭
纳米微粒
口腔癌
淋巴转移
pingyangmycin
activated carbon
nanoparticle
oral cancer
lymph metastasis
