摘要
目的:研究颈椎病发生中突出颈椎间盘组织的炎症反应机制,探讨炎症反应在颈椎间盘退变和颈椎病发病中的作用。方法:临床收集了31个脊髓型颈椎病病人的35个突出的颈椎间盘标本和3个成年人的7个正常颈椎间盘标本。将每个标本分为2份,1份作组织学检查,观察有无炎细胞浸润,1份用生物化学方法测定其中IL-1α,IL-6和TNF-α三种细胞因子含量。结果:35例突出颈间盘中,18例(51.4%)在边缘区域有大量炎细胞浸润,其余17例(48.6%)未见炎细胞浸润,对照组也未见炎细胞浸润。生物化学测定结果表明,突出颈间盘组织中IL一1α,IL-6和TNF-α三种细胞因子含量明显高于正常对照组。炎细胞浸润组与无炎细胞浸润组三种细胞因子含量相当,在统计学上无任何差异。结论:突出颈间盘组织具有炎症反应特性,炎症反应可能在颈椎间盘退变和颈椎病的发生发展中起重要作用。
Objective:To study the inflammatory mechanism of herniated cervical Intervertebral discs from patients with cervical spondylotic myelopathy, and the roles of the inflammation in the cervical disc degeneration and cervical spondylosis. Methods: 35 herniated cervical discs were obtained from 31 patients with cervical spondylotic myeloyathy during the anterior cervical surgery. 7 normal, nondegenerated cervical discs(control group) were obtained from three fresh cadavers. All discs were divided into two samples, one of which was used as histologic examination, and the other was used to detect contents of IL-1α, IL-6 and TNF-α biochemically. Results: In 35 herniated cervical discs, 18 (51.4%) abundant inflammatory cells were shown infiltration in margin of herniated discs; 17(48.6%) showed no inflammatory cell infiltration; normal discs also did not show any inflammatory cell infiltration. Biochemical assay indicated that the contents of eytokines IL-1α , IL-6 and TNF-α were obviously higher than that of normal discs, and the contents of cytokines showed no difference between discs with inflammatory cell infiltration and discs with no inflammatory cell infiltrates. Conclusion: Herniated cervical disc from the cervical spondylotic myelopathy was inflammatory, and inflammation may play an important role in cervical disc degeneration and in pathogenesis of cervical spondylosis.
出处
《感染．炎症．修复》
2000年第1期23-26,共4页
Infection Inflammation Repair
关键词
颈椎间盘
退变
突出
炎症
细胞因子
Cervical intervertebral disc Herniation Degeneration Inflammation Cytokines
