高血压心血管重构过程中转化生长因子β的作用被引量：1

The Important role of Transforming Growth Factor-β in Pro-cess of Cardiovascular Remodeling of Hypertension

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摘要转化生长因子β(TGF-β)是一种对细胞的生长、分化和多种生理、病理过程起重要调节作用的细胞因子。本文综述了近年来国内外关于TGF-β在高血压心血管重构过程中的作用方面所取得的最新研究进展。介绍了TGF-β的结构和作用方式,并着重介绍了TGF-β对RAS系统及内皮细胞的作用和对血管平滑肌增殖及血管重塑的影响。 Transforming growth factor-β (TGF-β) is a kind of multifunction cytokines, stimulatescyto-production, participates cells proliferation, plays a crucial role in regulating the course ofphysiology and path-physiology after hypertension. This article summarized the newest research progres-sive of TGF-β in cardiovascular remodeling of hypertension by recently in nation wide and global. Themolecular structure and function of TGF-β in relation to rein angiotension system, interferingendothelia function, enhancing proliferation process of smooth muscle cells was highlighted in detail.

作者苏焕群高修仁

机构地区广东省医学情报研究所中山大学附属第一医院心内科

出处《国际医药卫生导报》 2003年第22期4-6,共3页 International Medicine and Health Guidance News

关键词转化生长因子Β 高血压心血管重构综述文献 Transforming growth factor β Hypertension Cardiovascular remodeling Review

分类号 R544.1 [医药卫生—心血管疾病]

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1[1]Delarco JE, Todaro GJ. Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci USA, 1978, 75(8) : 4001-4005
2[2]Brown CB, Boyer AS, Runan RB, et al. Requirement of type Ⅲ TGF-beta receptor for endocardial cell trasformation in the heart. Science, 1999, 283(5410):2080-2082
3[3]Derynck R, Zhang Y, Feng XH. Smads:Transcriptional activators of TGF-β. Responses . Cell, 1998, 95(6):737-740
4[4]Huang H Y, Wen Y, Irwin J C, et al. Cytokine-mediated regulation of 92-kilodalton type Ⅳ collagenase, tissue inhibitor or metallgoroteinase-1 (TIMP-1) and TIMP3.messenger ribonueleic acid expression in human endometrial stromal cells. J Clin Endocrinol. Metab,1998, 83(5): 1721-1729
5[5]Warner BJ, Blain SE, Seoane J, et al. Myc down regulation by transforming growth factor-beta required for activation of the p15(Ink4b) G(1) arrest pathway . Mol Cell Biol, 1999, 19(9):5913 -5922
6[6]Grohe C, Kahlert LC. Angiotensin converting enzyme inhibition modulate cardiac fibroblast growth.Hypertension. 1998,16:377-384
7[7]Campbell SE, Katwa LC. Angiotensin Ⅱ stimulated expression of transforming growth factor β1 in cardiac fibroblasts and myofibroblasts .J Mol Cell Cardio,1997,29:1947-1958
8[8]Wayne A, Border, Nancy A, et al. Interaction of transforming growth factor-β and angiotension Ⅱ in renal fibrosis .Hypretension, 1998,3 (pt2):181-188
9[9]Kagamis, Border WA, Miller DE, et al. Angiotension Ⅱ Stimulates extracellular matrix protein synthesis through induction of transforming growth factor- β expression in rat glomerular mesangial cells . J Clin Invest, 1994,93 (6):2431-2437
10[10]Lee L, Meyer TW, Pollock AS, et al. Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney .J Clin Inrest, 1995,96:953-964