摘要
目的 探讨金属蛋白酶在股骨头坏死过程中导致关节软骨破坏的作用。方法 临床上采集激素性股骨头坏死、原发性髋关节骨性关节炎及新鲜股骨头 /颈骨折患者股骨头关节软骨 ,切片后进行免疫组化检测 MMP- 1、MMP- 13及 TIMP- 1的表达。结果 股骨头坏死、原发性髋关节骨性关节炎关节软骨均有较强的 MMP- 1、MMP- 13表达及 TIMP- 1较低水平的表达。
Objective In order to expound the effect of MMP in articular cartilage destroyed of ANFH.Methods In clinical we collected articular cartilage of GANFH(glucoticorticoid-induced avascular necrosis of the femoral head),OA of prime hip joint,and fresh fracture of head/neck of femur,After sliced,the expression of MMP-1、MMP-13 and TIMP-1 was detected.Results That cartilage of ANFH and OA of prime hip joint had higher expression of MMP-1、MMP-13,but lower expression of TIMP-1.Conclusion MMP has the important effects in articular cartilage destroyed of ANFH.
出处
《实用骨科杂志》
2004年第3期224-226,共3页
Journal of Practical Orthopaedics
关键词
股骨头坏死
金属蛋白酶
关节软骨破坏
免疫组化
检测
matrix metalloproteinases(MMPs)
avascular necrosis of the femoral head(ANFH)
articular cartilage
